Trintellix and Maxalt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trintellix (vortioxetine hydrobromide) and Maxalt (rizatriptan benzoate). Common drug interactions include paralysis among females and urinary tract infection among males.

The phase IV clinical study analyzes what interactions people have when they take Trintellix and Maxalt. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

What is Maxalt?

Maxalt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 12,754 Maxalt users. Check the latest studies of Maxalt.

On Jul, 07, 2026

90 people who take Trintellix and Maxalt together, and have interactions are studied.

Trintellix and Maxalt drug interactions.

What are the common drug interactions of Trintellix and Maxalt, by gender? *:

female:

Paralysis
Platelet count decreased
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Thirst
Upper limb fracture
Hot flush (sudden feelings of heat)
Nephrolithiasis (calculi in the kidneys)
Shoulder operation

male:

Urinary tract infection
Diarrhoea
Respiratory tract congestion (blockage on respiratory system)
Testicular pain (pain in testes)
Wheezing (a high-pitched whistling sound made while you breath)
Dry mouth
Arthralgia (joint pain)
Blood pressure increased
Fall
Fungal skin infection

What are the common drug interactions of Trintellix and Maxalt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cough
Dry eye (lack of adequate tears)
Head discomfort
Sinusitis (inflammation of sinus)
Drug hypersensitivity
Cartilage injury
Disability
Psychiatric symptom

30-39:

Meningioma (a diverse set of tumours arising from the meninges)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Behcet's syndrome (involves inflammation of the blood vessels)
Diarrhoea
Incoherent (talking in a confused and unclear way)
Incontinence (lack of moderation or self-control)
Muscle contractions involuntary (uncontrolled muscle contraction)
Nausea (feeling of having an urge to vomit)
Vomiting

40-49:

Localised infection (infection at the single location)
Mobility decreased (ability to move is reduced)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Nausea (feeling of having an urge to vomit)
Optic neuritis (optic nerve inflammation)
Osteonecrosis (death of bone)
Pain in extremity
Sinusitis (inflammation of sinus)
Thrombosis (formation of a blood clot inside a blood vessel)

50-59:

Urinary tract infection
Nausea (feeling of having an urge to vomit)
Anxiety
Breast cancer
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Muscle spasms (muscle contraction)
Panic attack
Pruritus (severe itching of the skin)
Fatigue (feeling of tiredness)
Hot flush (sudden feelings of heat)

60+:

Sinusitis (inflammation of sinus)
Pneumonia
Death
Eye irritation
Fatigue (feeling of tiredness)
Feeling jittery
Foot fracture
Haematemesis (vomiting of blood)
Infusion related reaction
Insomnia (sleeplessness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 54 people, 60.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 15.56%
High Blood Pressure: 13 people, 14.44%
Stress And Anxiety: 12 people, 13.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 10.00%
Hypersensitivity: 8 people, 8.89%
Muscle Spasms (muscle contraction): 8 people, 8.89%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 7.78%
Skin Disorder (skin disease): 6 people, 6.67%
Pain: 6 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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