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Trintellix and Ranexa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trintellix (vortioxetine hydrobromide) and Ranexa (ranolazine). Common drug interactions include gallbladder operation among females and urinary tract infection among males.

The phase IV clinical study analyzes what interactions people have when they take Trintellix and Ranexa. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

What is Ranexa?

Ranexa has active ingredients of ranolazine. It is often used in angina. eHealthMe is studying from 11,758 Ranexa users. Check the latest studies of Ranexa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

20 people who take Trintellix and Ranexa together, and have interactions are studied.

Trintellix and Ranexa drug interactions.

What are the common drug interactions of Trintellix and Ranexa, by gender? *:

female:

  1. Gallbladder operation
  2. Abdominal pain upper
  3. Anaemia (lack of blood)
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Cardiac failure
  6. Dyspnoea (difficult or laboured respiration)
  7. Insomnia (sleeplessness)
  8. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  9. Nausea (feeling of having an urge to vomit)
  10. Nightmare (unpleasant dream)

male:

  1. Urinary tract infection
  2. Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
  3. Anxiety
  4. Blood pressure decreased
  5. Blood pressure fluctuation
  6. Chronic kidney disease
  7. Emotional distress
  8. Face injury
  9. Feeling cold
  10. Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Trintellix and Ranexa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Urinary tract infection
  2. Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
  3. Diarrhoea
  4. Fall
  5. Fungal skin infection
  6. Hypokalaemia (low potassium)
  7. Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
  8. Urinary tract infection bacterial
  9. Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
  10. Gallbladder operation

50-59:

  1. Urinary tract infection
  2. Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
  3. Diarrhoea
  4. Fall
  5. Fungal skin infection
  6. Hypokalaemia (low potassium)
  7. Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
  8. Urinary tract infection bacterial
  9. Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)

60+:

  1. Blood pressure decreased
  2. Blood pressure fluctuation
  3. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  4. Cardiac failure
  5. Insomnia (sleeplessness)
  6. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  7. Nausea (feeling of having an urge to vomit)
  8. Vomiting psychogenic
  9. Face injury
  10. Feeling cold

What are the existing conditions these people have? *

  1. Stress And Anxiety: 8 people, 40.00%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 40.00%
  3. High Blood Pressure: 7 people, 35.00%
  4. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 35.00%
  5. Insomnia (sleeplessness): 6 people, 30.00%
  6. Constipation: 5 people, 25.00%
  7. Migraine (headache): 4 people, 20.00%
  8. Back Pain: 4 people, 20.00%
  9. Bladder Spasm: 4 people, 20.00%
  10. Carotid Artery Disease: 4 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Trintellix and Ranexa?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Trintellix and Ranexa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Trintellix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ranexa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Trintellix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ranexa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on vortioxetine hydrobromide and ranolazine (the active ingredients of Trintellix and Ranexa, respectively), and Trintellix and Ranexa (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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