Trokendi xr and Abilify drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trokendi xr (topiramate) and Abilify (aripiprazole). Common drug interactions include vomiting among females and ageusia among males.

The phase IV clinical study analyzes what interactions people have when they take Trokendi xr and Abilify. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Trokendi xr?

Trokendi xr has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 1,790 Trokendi xr users. Check the latest studies of Trokendi xr.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,454 Abilify users. Check the latest studies of Abilify.

On Jul, 08, 2026

19 people who take Trokendi xr and Abilify together, and have interactions are studied.

Trokendi xr and Abilify drug interactions.

What are the common drug interactions of Trokendi Xr and Abilify, by gender? *:

female:

Vomiting
Abnormal behaviour
Abnormal dreams
Anxiety
Cold sweat
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Drug withdrawal headache
Duodenogastric reflux (bile flows upward from the small intestine into the stomach)
Electrocardiogram t wave inversion

male:

Ageusia (loss of taste functions of the tongue)
Aphasia (damage to the parts of the brain that control language)
Anxiety
Back disorder
Balance disorder
Dizziness
Drug level decreased
Eructation (release of gas from the digestive tract)
Fibromyalgia (a long-term condition which causes pain all over the body)
Mood altered (changes in mood)

What are the common drug interactions of Trokendi Xr and Abilify, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Fall
Keratosis pilaris (a condition in which there are numerous rough follicular spots, which may be skin coloured, red or brown)
Seborrhoeic dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp)
Enuresis (repeated inability to control urination)

10-19:

n/a

20-29:

Abnormal behaviour
Drug level decreased

30-39:

Cluster headache (one-sided head pain with tearing)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Self-injurious ideation
Vomiting

40-49:

Altered state of consciousness (altered state of mind)
Chest pain
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Abnormal dreams
Ageusia (loss of taste functions of the tongue)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Cold sweat
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Drug withdrawal headache
Duodenogastric reflux (bile flows upward from the small intestine into the stomach)
Electrocardiogram t wave inversion

60+:

Anaemia (lack of blood)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Change of bowel habit
Constipation
Diarrhoea
Fall
Hemiparesis (weakness on one side of the body)
Joint dislocation (a joint position is changed from normal position)
Limb injury

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 52.63%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 1 person, 5.26%
Sinusitis (inflammation of sinus): 1 person, 5.26%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.26%
Pain: 1 person, 5.26%
Neuropathy Peripheral (surface nerve damage): 1 person, 5.26%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 5.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.26%
Intervertebral Disc Protrusion (spinal disc protrusion): 1 person, 5.26%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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