Trulance and Rinvoq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trulance (plecanatide) and Rinvoq (upadacitinib). Common drug interactions include back pain among females and surgery among males.

The phase IV clinical study analyzes what interactions people have when they take Trulance and Rinvoq. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Trulance?

Trulance has active ingredients of plecanatide. eHealthMe is studying from 1,746 Trulance users. Check the latest studies of Trulance.

What is Rinvoq?

Rinvoq has active ingredients of upadacitinib. eHealthMe is studying from 47,375 Rinvoq users. Check the latest studies of Rinvoq.

On Jul, 11, 2026

12 people who take Trulance and Rinvoq together, and have interactions are studied.

What are the common drug interactions of Trulance and Rinvoq, by gender? *:

female:

Back pain
Gait disturbance
Hand fracture
Knee arthroplasty
Limb discomfort (discomfort in leg)
Localised infection (infection at the single location)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nail bed disorder (disease of nail bed)
Neoplasm malignant (cancer tumour)
Nerve root injury lumbar (nerve root injury at the lumber vertebra)

male:

Surgery

What are the common drug interactions of Trulance and Rinvoq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Tendonitis (a condition that causes pain and swelling of tendons)
Back pain
Cartilage injury
Gait disturbance
Limb discomfort (discomfort in leg)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nerve root injury lumbar (nerve root injury at the lumber vertebra)
Pain
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Shoulder operation

60+:

Erythema (redness of the skin)
Hand fracture
Localised infection (infection at the single location)
Nail bed disorder (disease of nail bed)
Onychalgia (nail biting)
Purulence (containing pus)
Surgery

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 100.00%
Muscle Spasms (muscle contraction): 2 people, 16.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 16.67%
Pain: 1 person, 8.33%
Oral Mucosal Blistering (mouth ulcer): 1 person, 8.33%
Neuralgia (pain in one or more nerves): 1 person, 8.33%
Nasal Inflammation (inflammation of nose): 1 person, 8.33%
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 1 person, 8.33%
Joint Pain: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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