Trulicity and Morphine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trulicity (dulaglutide) and Morphine sulfate (morphine sulfate). Common drug interactions include limb injury among females and coma among males.

The phase IV clinical study analyzes what interactions people have when they take Trulicity and Morphine sulfate. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,261 Morphine sulfate users. Check the latest studies of Morphine sulfate.



On Jul, 07, 2026

64 people who take Trulicity and Morphine sulfate together, and have interactions are studied.

Trulicity and Morphine sulfate drug interactions.

What are the common drug interactions of Trulicity and Morphine Sulfate, by gender? *:

female:

  1. Limb injury
  2. Mucosal inflammation (infection of mucous membrane)
  3. Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  4. Polyp
  5. Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
  6. Rash
  7. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  8. Road traffic accident
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Swelling

male:

  1. Coma (state of unconsciousness lasting more than six hours)
  2. Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
  3. Dyspnoea (difficult or laboured respiration)
  4. Fatigue (feeling of tiredness)
  5. Hallucination (an experience involving the perception of something not present)
  6. Nausea (feeling of having an urge to vomit)
  7. Sepsis (a severe blood infection that can lead to organ failure and death)
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Overdose
  10. Abdominal distension

What are the common drug interactions of Trulicity and Morphine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Coma (state of unconsciousness lasting more than six hours)
  2. Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
  3. Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
  4. Poisoning deliberate
  5. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  6. Overdose
  7. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  8. Anxiety
  9. Bone density decreased
  10. Bone pain

50-59:

  1. Bladder cancer
  2. Cystitis (inflammation of the wall of the bladder)
  3. Asthenia (weakness)
  4. Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
  5. Urinary tract infection
  6. Malaise (a feeling of general discomfort or uneasiness)
  7. Osteomyelitis acute (rapid infection of bone)
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  9. Cardiac murmur (an heart sound in valve abnormality)
  10. Chronic kidney disease

60+:

  1. Decreased appetite
  2. Angioedema (rapid swelling of the dermis)
  3. Diabetes mellitus inadequate control
  4. Hypoglycaemia (deficiency of glucose in the bloodstream)
  5. Abdominal distension
  6. Acute myocardial infarction (acute heart attack)
  7. Arthralgia (joint pain)
  8. Back injury
  9. Chronic kidney disease
  10. Death

What are the existing conditions these people have? *

  1. Diabetes: 15 people, 23.44%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 21.88%
  3. High Blood Cholesterol: 14 people, 21.88%
  4. Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 13 people, 20.31%
  5. Hyperthyroidism (over activity of the thyroid gland): 13 people, 20.31%
  6. Constipation: 13 people, 20.31%
  7. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 18.75%
  8. Poisoning Deliberate: 11 people, 17.19%
  9. Type 2 Diabetes: 7 people, 10.94%
  10. Multiple Myeloma (cancer of the plasma cells): 7 people, 10.94%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Trulicity and Morphine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Trulicity:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Morphine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Trulicity and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Morphine sulfate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on dulaglutide and morphine sulfate (the active ingredients of Trulicity and Morphine sulfate, respectively), and Trulicity and Morphine sulfate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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