Trulicity and Plaquenil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trulicity (dulaglutide) and Plaquenil (hydroxychloroquine sulfate). Common drug interactions include pleuritic pain among females and oxygen saturation decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Trulicity and Plaquenil. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,018 Plaquenil users. Check the latest studies of Plaquenil.

On Jul, 13, 2026

72 people who take Trulicity and Plaquenil together, and have interactions are studied.

Trulicity and Plaquenil drug interactions.

What are the common drug interactions of Trulicity and Plaquenil, by gender? *:

female:

Pleuritic pain
Vertigo
Abdominal distension
Abnormal loss of weight
Anaphylactic reaction (serious allergic reaction)
Antinuclear antibody increased
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthrodesis
Arthropathy
Autoimmune hepatitis

male:

Oxygen saturation decreased
Weight decreased
Dental caries
Diabetes mellitus inadequate control
Disturbance in attention
Drug hypersensitivity
Drug ineffective
Drug intolerance (drug sensitivity)
Fluid intake reduced
Fungal skin infection

What are the common drug interactions of Trulicity and Plaquenil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fatigue (feeling of tiredness)
Food poisoning (poison in food)
Gastrointestinal infection (infection of stomach and intestine)
Headache (pain in head)
Myalgia (muscle pain)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Otitis media (inflammation of the middle ear)
Pain
Poor venous access

40-49:

Blood glucose fluctuation
Blood thyroid stimulating hormone increased
Cerebral thrombosis (blood clot in brain)
Constipation
Decreased appetite
Diarrhoea
Fatigue (feeling of tiredness)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Nausea (feeling of having an urge to vomit)

50-59:

Pruritus (severe itching of the skin)
Renal injury (kidney injury)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Right ventricular failure (right half of the heart fails to work)
Skin exfoliation (removal of the oldest dead skin cells)
Skin lesion
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Surgery
Tooth infection

60+:

Bicytopenia (two parameters from the full blood count are low, the term bicytopenia can be used)
Hyperkalaemia (damage to or disease of the kidney)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Colitis (inflammation of colon)
Cough
Dental caries
Depression
Diabetes mellitus inadequate control
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 20 people, 27.78%
Diabetes: 13 people, 18.06%
Type 2 Diabetes: 11 people, 15.28%
Stiff Person Syndrome: 10 people, 13.89%
High Blood Cholesterol: 10 people, 13.89%
Immunodeficiency Common Variable: 8 people, 11.11%
Joint Pain: 7 people, 9.72%
High Blood Pressure: 7 people, 9.72%
Antisynthetase Syndrome (chronic autoimmune disease of unknown cause): 5 people, 6.94%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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