Trulicity and Sitagliptin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trulicity (dulaglutide) and Sitagliptin (sitagliptin). Common drug interactions include respiratory failure among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Trulicity and Sitagliptin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

What is Sitagliptin?

Sitagliptin has active ingredients of sitagliptin. eHealthMe is studying from 3,933 Sitagliptin users. Check the latest studies of Sitagliptin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

21 people who take Trulicity and Sitagliptin together, and have interactions are studied.

Trulicity and Sitagliptin drug interactions.

What are the common drug interactions of Trulicity and Sitagliptin, by gender? *:

female:

Respiratory failure (inadequate gas exchange by the respiratory system)
Abnormal loss of weight
Blood pressure increased
Chronic kidney disease
Diabetic complication
Gastritis (inflammation of stomach)
Intraductal papillary mucinous neoplasm (tumour (neoplasm) that grows within the pancreatic ducts)
Lipase increased
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Oxygen consumption increased

male:

Weight decreased
Blood glucose decreased
Hypertension (high blood pressure)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Oxygen saturation decreased
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Tooth disorder (tooth disease)
Tooth fracture
Weight increased
Angina pectoris (chest pain due to ischemia of the heart muscle)

What are the common drug interactions of Trulicity and Sitagliptin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal discomfort
Abdominal distension
Diarrhoea
Eye disorder
Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site swelling
Nausea (feeling of having an urge to vomit)
Vomiting

60+:

Weight decreased
Blood glucose decreased
Hypertension (high blood pressure)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Oxygen saturation decreased
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Tooth disorder (tooth disease)
Tooth fracture
Weight increased
Angina pectoris (chest pain due to ischemia of the heart muscle)

What are the existing conditions these people have? *

Diabetes: 8 people, 38.10%
Type 2 Diabetes: 7 people, 33.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 14.29%
Pneumonia: 2 people, 9.52%
High Blood Pressure: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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