Truvada and Epipen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Truvada (emtricitabine; tenofovir disoproxil fumarate) and Epipen (epinephrine). Common drug interactions include knee arthroplasty among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Truvada and Epipen. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

On Jul, 17, 2026

44 people who take Truvada and Epipen together, and have interactions are studied.

What are the common drug interactions of Truvada and Epipen, by gender? *:

female:

Knee arthroplasty
Multiple fractures
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Renal disorder (kidney disease)

male:

Anxiety
Pain
Decreased activity
Mobility decreased (ability to move is reduced)
Bone loss
Tooth loss
Renal failure (kidney dysfunction)
Impaired work ability
Rib fracture
Blood creatinine increased

What are the common drug interactions of Truvada and Epipen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Pain
Bone disorder
Decreased activity
Osteonecrosis (death of bone)
Quality of life decreased
Complications of transplanted kidney

40-49:

Dizziness
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Decreased activity
Depression
Emotional distress

50-59:

Emotional distress
Pain
Chronic kidney disease
Osteoporosis (bones weak and more likely to break)
Bone loss
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)
Bone density decreased
Tooth loss
Blood creatinine increased

60+:

Anaemia (lack of blood)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Drug screen positive
Nephropathy (damage to or disease of a kidney)
Osteoporosis (bones weak and more likely to break)
Proteinuria (presence of protein in the urine)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

What are the existing conditions these people have? *

Hypersensitivity: 10 people, 22.73%
Pain: 7 people, 15.91%
Infection: 7 people, 15.91%
Insomnia (sleeplessness): 6 people, 13.64%
High Blood Pressure: 6 people, 13.64%
Depression: 6 people, 13.64%
Nausea (feeling of having an urge to vomit): 5 people, 11.36%
Herpes Virus Infection: 5 people, 11.36%
High Blood Cholesterol: 5 people, 11.36%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 5 people, 11.36%

* Approximation only. Some reports may have incomplete information.

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