Truvada and Lortab drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Truvada (emtricitabine; tenofovir disoproxil fumarate) and Lortab (acetaminophen; hydrocodone bitartrate). Common drug interactions include abortion spontaneous among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Truvada and Lortab. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

What is Lortab?

Lortab has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 31,285 Lortab users. Check the latest studies of Lortab.

On Jul, 14, 2026

51 people who take Truvada and Lortab together, and have interactions are studied.

What are the common drug interactions of Truvada and Lortab, by gender? *:

female:

Abortion spontaneous (naturally occurring miscarriage)
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Anaemia (lack of blood)
Asthenia (weakness)
Balance disorder
Bilirubin conjugated increased
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood bilirubin increased
Blood uric acid increased

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Ankle fracture
Gait disturbance
Blood creatinine increased
Depression
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Osteopenia (a condition where bone mineral density is lower than normal)
Bone loss
Bone pain

What are the common drug interactions of Truvada and Lortab, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Bone loss
Emotional distress
Osteonecrosis (death of bone)
Pathogen resistance
Tooth loss

30-39:

Anxiety
Bone density decreased
Gait disturbance
Fracture
Hip fracture
Osteoporosis (bones weak and more likely to break)
Spinal fracture (fracture in one of vertebrae)
Depression
Emotional distress
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

40-49:

Mood altered (changes in mood)
Muscular weakness (muscle weakness)
Nephrolithiasis (calculi in the kidneys)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Tooth loss
Emotional distress
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Bone density decreased

50-59:

Anxiety
Emotional distress
Osteoporosis (bones weak and more likely to break)
Chronic kidney disease
Dysstasia (difficulty in standing)
Osteopenia (a condition where bone mineral density is lower than normal)
Bone density decreased
Depression
Gait disturbance
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Low birth weight baby
Premature baby
Renal cancer (cancer of kidney)
Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 11.76%
Nausea (feeling of having an urge to vomit): 4 people, 7.84%
High Blood Pressure: 4 people, 7.84%
Bacterial Infection: 4 people, 7.84%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 5.88%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 5.88%
Depression: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Truvada and Lortab?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously