Tryptophan and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tryptophan (l - tryptophan) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include pain among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Tryptophan and Benadryl. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Tryptophan?

Tryptophan has active ingredients of l - tryptophan. eHealthMe is studying from 700 Tryptophan users. Check the latest studies of Tryptophan.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,956 Benadryl users. Check the latest studies of Benadryl.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 02, 2026

28 people who take Tryptophan and Benadryl together, and have interactions are studied.

Tryptophan and Benadryl drug interactions.

What are the common drug interactions of Tryptophan and Benadryl, by gender? *:

female:

Pain
Abdominal pain upper
Breast abscess
Electrocardiogram qt prolonged
Fatigue (feeling of tiredness)
Impaired healing
Lower respiratory tract infection
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Neck pain
Oropharyngeal pain

male:

Pain
Blood pressure increased
Hypertension (high blood pressure)
Drug ineffective

What are the common drug interactions of Tryptophan and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Back pain
Nasopharyngitis (inflammation of the nasopharynx)
Abdominal pain upper
Breast abscess
Cough
Electrocardiogram qt prolonged
Fall
Fatigue (feeling of tiredness)
Impaired healing
Lower respiratory tract infection

60+:

Cough
Pneumonia
Contusion (a type of hematoma of tissue in which capillaries)
Blood oestrogen increased
Blood testosterone increased
Blood thyroid stimulating hormone decreased
Dysuria (painful or difficult urination)
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Inflammation

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 32.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 21.43%
Sleep Disorder: 4 people, 14.29%
Pneumonia: 3 people, 10.71%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 3 people, 10.71%
Medullary Thyroid Cancer (type of thyroid cancer that develops in the parafollicular cells of the thyroid gland): 3 people, 10.71%
Depression: 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

Do you take Tryptophan and Benadryl?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously