Tylenol w/ codeine and Neupogen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Neupogen (filgrastim). Common drug interactions include musculoskeletal stiffness among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Neupogen. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Neupogen?

Neupogen has active ingredients of filgrastim. It is often used in agranulocytosis. eHealthMe is studying from 23,898 Neupogen users. Check the latest studies of Neupogen.

On Jul, 13, 2026

69 people who take Tylenol w/ codeine and Neupogen together, and have interactions are studied.

Tylenol w/ codeine and Neupogen drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Neupogen, by gender? *:

female:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain of skin
Scar
Skin exfoliation (removal of the oldest dead skin cells)
Skin fibrosis (fibrous tissue formation on skin)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Skin plaque (red, scaly patches to appear on the skin)

male:

Pyrexia (fever)
Anxiety
Reflux oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus)
Upper respiratory tract infection
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Attention deficit/hyperactivity disorder
Depression
Lung neoplasm (tumour of lung)
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Bipolar disorder (mood disorder)

What are the common drug interactions of Tylenol W/ Codeine and Neupogen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

B-cell lymphoma (blood cancer affecting b cells)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Conjunctivitis (pink eye)
Cough
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Eczema eyelids (patches of skin become rough and inflamed, with itching and bleeding blisters on eyelid)
Pyrexia (fever)
Reflux oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus)
Rhinitis allergic (inflammation of the nasal airways due to allergy)

10-19:

Pyrexia (fever)
Epiphyseal disorder
Hypersensitivity
Kidney transplant rejection
Postoperative wound complication
Pulmonary infarction (death of a small area of lung)
Thrombosis (formation of a blood clot inside a blood vessel)

20-29:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Myopathy (a muscular disease in which the muscle fibres do not function)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Peroneal nerve palsy
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Scar
Skin atrophy (wasting of skin)
Skin depigmentation (lightening of the skin)

30-39:

n/a

40-49:

n/a

50-59:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Cellulitis (infection under the skin)
Deformity (disfigurement)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)

60+:

Cystitis haemorrhagic (blood in the urine and painful voiding)
Fatigue (feeling of tiredness)
Adult respiratory distress syndrome (type of lung (pulmonary) failure)
Agitation (state of anxiety or nervous excitement)
Drug ineffective
Flatulence (flatus expelled through the anus)
Haematocrit decreased
Heart rate increased
Ileus (a painful obstruction of the ileum or other part of the intestine)
Intestinal obstruction

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 18 people, 26.09%
Nuclear Magnetic Resonance Imaging Brain: 16 people, 23.19%
Depression: 13 people, 18.84%
Stress And Anxiety: 12 people, 17.39%
Herpes Zoster: 12 people, 17.39%
Device Related Infection: 12 people, 17.39%
Gastritis Erosive (a break in the surface layer of the membrane lining the stomach with infection): 12 people, 17.39%
High Blood Cholesterol: 12 people, 17.39%
Itching: 12 people, 17.39%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 10 people, 14.49%

* Approximation only. Some reports may have incomplete information.

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