Tylenol and Tepezza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol (acetaminophen) and Tepezza (teprotumumab-trbw). Common drug interactions include muscle spasms among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol and Tepezza. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,309 Tylenol users. Check the latest studies of Tylenol.

What is Tepezza?

Tepezza has active ingredients of teprotumumab-trbw. eHealthMe is studying from 3,632 Tepezza users. Check the latest studies of Tepezza.

On Jul, 19, 2026

23 people who take Tylenol and Tepezza together, and have interactions are studied.

What are the common drug interactions of Tylenol and Tepezza, by gender? *:

female:

Muscle spasms (muscle contraction)
Oropharyngeal pain
Deafness
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Autophony (hearing one's voice in one's own ear)
Blood glucose fluctuation
Blood glucose increased
Diarrhoea
Diplopia (double vision)

male:

Fatigue (feeling of tiredness)
Abdominal pain
Dyspepsia (indigestion)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Anxiety
Arthralgia (joint pain)
Diplopia (double vision)
Dizziness
Eye pain

What are the common drug interactions of Tylenol and Tepezza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)

40-49:

Diarrhoea
Fatigue (feeling of tiredness)
Hyperglycaemia (high blood sugar)
Blood glucose increased
Dyspepsia (indigestion)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Abdominal pain
Anxiety
Arthralgia (joint pain)

50-59:

n/a

60+:

Muscle spasms (muscle contraction)
Deafness
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)
Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Oropharyngeal pain
Rash
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Tinnitus (a ringing in the ears)

What are the existing conditions these people have? *

Endocrine Ophthalmopathy (increased water content of retroocular orbital tissues; associated with thyroid disease, usually hyperthyroidism): 14 people, 60.87%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 3 people, 13.04%
Hyperthyroidism (over activity of the thyroid gland): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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