Wellbutrin and Euthyrox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Wellbutrin (bupropion hydrochloride) and Euthyrox (levothyroxine sodium). Common drug interactions include hallucination, auditory among females and arachnoiditis among males.

The phase IV clinical study analyzes what interactions people have when they take Wellbutrin and Euthyrox. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Euthyrox?

Euthyrox has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,740 Euthyrox users. Check the latest studies of Euthyrox.



On Jul, 19, 2026

45 people who take Wellbutrin and Euthyrox together, and have interactions are studied.

Wellbutrin and Euthyrox drug interactions.

What are the common drug interactions of Wellbutrin and Euthyrox, by gender? *:

female:

  1. Hallucination, auditory (perceiving sounds without auditory stimulus)
  2. Oesophageal hypomotility (low movement of oesophagus)
  3. Oesophageal spasm (contraction of oesophagus)
  4. Psychotic behaviour
  5. Alopecia (absence of hair from areas of the body)
  6. Constipation
  7. Dry skin
  8. Ephelides (tanned macules found on the skin)
  9. Hallucination (an experience involving the perception of something not present)
  10. Neck mass (mass in neck)

male:

  1. Arachnoiditis (neuropathic disease caused by inflammation of the arachnoid)
  2. Haemochromatosis (body to absorb more iron than usual from food)
  3. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
  4. Weight decreased
  5. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  6. Surgery

What are the common drug interactions of Wellbutrin and Euthyrox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Arthralgia (joint pain)
  2. Oedema (fluid collection in tissue)
  3. Urticaria (rash of round, red welts on the skin that itch intensely)

20-29:

  1. Hallucination, auditory (perceiving sounds without auditory stimulus)
  2. Psychotic behaviour
  3. Rash
  4. Urticaria (rash of round, red welts on the skin that itch intensely)
  5. Hallucination (an experience involving the perception of something not present)
  6. Drug dependence

30-39:

n/a

40-49:

  1. Arachnoiditis (neuropathic disease caused by inflammation of the arachnoid)
  2. Weight decreased
  3. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  4. Haematochezia (passage of stools containing blood)
  5. Surgery

50-59:

  1. Oesophageal hypomotility (low movement of oesophagus)
  2. Oesophageal spasm (contraction of oesophagus)
  3. Blood pressure increased
  4. Carcinoid tumour (slow growing tumour)
  5. Cardiac failure
  6. Chills (felling of cold)
  7. Haemochromatosis (body to absorb more iron than usual from food)
  8. Impaired driving ability
  9. Memory impairment
  10. Panic reaction

60+:

  1. Alopecia (absence of hair from areas of the body)
  2. Constipation
  3. Skin wrinkling (wrinkle on skin)
  4. Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
  5. Hepatic failure (liver failure)
  6. Dry skin
  7. Ephelides (tanned macules found on the skin)
  8. Neck mass (mass in neck)
  9. Onychoclasis (breaking of the nails)
  10. Pigmentation disorder (disturbances of human skin colour)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 28.89%
  2. Drowsiness: 10 people, 22.22%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin and Euthyrox?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Wellbutrin and Euthyrox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Wellbutrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Euthyrox:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Wellbutrin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Euthyrox and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride and levothyroxine sodium (the active ingredients of Wellbutrin and Euthyrox, respectively), and Wellbutrin and Euthyrox (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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