Tysabri and Maxalt-mlt drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tysabri (natalizumab) and Maxalt-mlt (rizatriptan benzoate). Common drug interactions include progressive multifocal leukoencephalopathy among females and anticonvulsant drug level increased among males.

The phase IV clinical study analyzes what interactions people have when they take Tysabri and Maxalt-mlt. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Tysabri?

Tysabri has active ingredients of natalizumab. It is often used in multiple sclerosis. eHealthMe is studying from 221,369 Tysabri users. Check the latest studies of Tysabri.

What is Maxalt-mlt?

Maxalt-mlt has active ingredients of rizatriptan benzoate. It is often used in migraine. eHealthMe is studying from 1,534 Maxalt-mlt users. Check the latest studies of Maxalt-mlt.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

23 people who take Tysabri and Maxalt-mlt together, and have interactions are studied.

Tysabri and Maxalt-mlt drug interactions.

What are the common drug interactions of Tysabri and Maxalt-Mlt, by gender? *:

female:

Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Fall
Urinary tract infection
Bladder dysfunction
Blindness unilateral
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Respiratory failure (inadequate gas exchange by the respiratory system)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Optic neuritis (optic nerve inflammation)

male:

Anticonvulsant drug level increased
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Bladder dysfunction
Fall
Hyperbilirubinaemia (excess of bilirubin in the blood)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Respiratory failure (inadequate gas exchange by the respiratory system)
Urinary tract infection

What are the common drug interactions of Tysabri and Maxalt-Mlt, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Bartholin's cyst (cyst is formed on one or both of the two bartholin's glands, which are located one on either side of the opening of the vagina)
Feeling hot
Ovarian cyst (fluid filled sac of the ovary)
Pelvic haematoma (collection of blood outside of a blood vessel in pelvic region)
Post procedural haemorrhage (post procedural bleeding)
Postictal state
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Pyrexia (fever)

50-59:

Fall
Urinary tract infection
Bladder dysfunction
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Respiratory failure (inadequate gas exchange by the respiratory system)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Opportunistic infection (a microorganism that normally does not cause disease but becomes pathogenic when the body's immune system is impaired and unable to fight)
Bladder disorder
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)

60+:

Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Bladder dysfunction
Fall
Hyperbilirubinaemia (excess of bilirubin in the blood)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Respiratory failure (inadequate gas exchange by the respiratory system)
Urinary tract infection

What are the existing conditions these people have? *

Pain: 13 people, 56.52%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 10 people, 43.48%
Stress And Anxiety: 9 people, 39.13%
Sleep Disorder: 9 people, 39.13%
Restless Leg Syndrome (a powerful urge to move your legs): 8 people, 34.78%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 8 people, 34.78%
Fibromyalgia (a long-term condition which causes pain all over the body): 8 people, 34.78%
Depression: 8 people, 34.78%
Cystitis Interstitial (unknown cause characterized by bladder pain): 8 people, 34.78%
Headache (pain in head): 6 people, 26.09%

* Approximation only. Some reports may have incomplete information.

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