Ubrelvy and Ultram drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ubrelvy (ubrogepant) and Ultram (tramadol hydrochloride). Common drug interactions include hypotension among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Ubrelvy and Ultram. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Ubrelvy?

Ubrelvy has active ingredients of ubrogepant. eHealthMe is studying from 3,585 Ubrelvy users. Check the latest studies of Ubrelvy.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

On Jul, 25, 2026

16 people who take Ubrelvy and Ultram together, and have interactions are studied.

What are the common drug interactions of Ubrelvy and Ultram, by gender? *:

female:

Hypotension (abnormally low blood pressure)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Fatigue (feeling of tiredness)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Migraine (headache)
Road traffic accident
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tremor (trembling or shaking movements in one or more parts of your body)
Vertebral foraminal stenosis (narrowing of the intervertebral foramen)

male:

Asthenia (weakness)
Back pain
Neck pain
Pain in jaw
Injection site pain
Insomnia (sleeplessness)
Presyncope
Chest pain
Constipation
Decreased appetite

What are the common drug interactions of Ubrelvy and Ultram, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Fatigue (feeling of tiredness)
Headache (pain in head)
Heart rate increased
Nausea (feeling of having an urge to vomit)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Tinnitus (a ringing in the ears)
Tremor (trembling or shaking movements in one or more parts of your body)
Visual impairment

30-39:

n/a

40-49:

Dysarthria (speech disorder)
Facial paralysis (loss of function of face muscle)
Hemiparesis (weakness on one side of the body)
Migraine (headache)

50-59:

Lymphopenia (an abnormally low level of lymphocytes in the blood)
White blood cell count decreased
Alcohol abuse
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug abuse
Dysphagia (a condition in which swallowing is difficult or painful)
Herpes simplex (herpes simplex is a common viral infection)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Spinal fusion surgery
Tremor (trembling or shaking movements in one or more parts of your body)

60+:

Hypotension (abnormally low blood pressure)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Hypovolaemia (a decreased volume of circulating blood in the body)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Migraine (headache)
Obesity (having too much body fat)
Obstructive sleep apnoea syndrome (frequent pauses in breathing during sleep usually accompanied by loud snoring)
Pelvi-ureteric obstruction (obstruction of the flow of urine from the renal pelvis to the proximal ureter)

What are the existing conditions these people have? *

Migraine (headache): 6 people, 37.50%
Migraine Without Aura (headache without neurological problems): 5 people, 31.25%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 25.00%
Headache (pain in head): 3 people, 18.75%
Status Migrainosus (a migraine headache for 72 hours): 2 people, 12.50%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 12.50%
Parkinson's Disease: 2 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 12.50%
Senile Osteoporosis (weak bones with ageing): 2 people, 12.50%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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