Uceris and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Uceris (budesonide) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include arthralgia among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Uceris and Benadryl. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Uceris?

Uceris has active ingredients of budesonide. It is often used in ulcerative colitis. eHealthMe is studying from 1,721 Uceris users. Check the latest studies of Uceris.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,954 Benadryl users. Check the latest studies of Benadryl.

On Jul, 23, 2026

16 people who take Uceris and Benadryl together, and have interactions are studied.

What are the common drug interactions of Uceris and Benadryl, by gender? *:

female:

Arthralgia (joint pain)
Contusion (a type of hematoma of tissue in which capillaries)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Feeling jittery
Flushing (the warm, red condition of human skin)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Immunosuppressant drug level decreased
Infusion related reaction
Laryngitis (inflammation of the larynx)

male:

Arthralgia (joint pain)
Device related infection
Dyspnoea (difficult or laboured respiration)
Joint swelling
Peripheral swelling
Pyrexia (fever)

What are the common drug interactions of Uceris and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Dyspnoea (difficult or laboured respiration)

10-19:

Device related infection
Feeling jittery
Flushing (the warm, red condition of human skin)
Infusion related reaction
Restless legs syndrome (a powerful urge to move your legs)

20-29:

Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop)
Alopecia (absence of hair from areas of the body)
Contusion (a type of hematoma of tissue in which capillaries)
Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum)
Skin lesion
Therapeutic response delayed (late preventive response)

30-39:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Skin papilloma (a general medical term for a tumour of the skin or mucous membrane with finger-like projections)

40-49:

n/a

50-59:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Laryngitis (inflammation of the larynx)

60+:

n/a

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 25.00%
Diarrhea: 3 people, 18.75%
Abdominal Pain: 3 people, 18.75%
Seasonal Allergy (allergic condition due to certain season): 3 people, 18.75%
Nausea (feeling of having an urge to vomit): 3 people, 18.75%
Melasma (the mask of pregnancy when present in pregnant women) is a tan or dark skin discoloration): 2 people, 12.50%
Bursitis Infective (the bursa can become infected, this is called infected bursitis): 2 people, 12.50%
Bone Disorder: 2 people, 12.50%
Food Allergy: 2 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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