Uloric and Vytorin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Uloric (febuxostat) and Vytorin (ezetimibe; simvastatin). Common drug interactions include myocardial infarction among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Uloric and Vytorin. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Uloric?

Uloric has active ingredients of febuxostat. It is often used in gout. eHealthMe is studying from 8,067 Uloric users. Check the latest studies of Uloric.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

On Jul, 10, 2026

41 people who take Uloric and Vytorin together, and have interactions are studied.

What are the common drug interactions of Uloric and Vytorin, by gender? *:

female:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Chronic kidney disease
Pleural effusion (water on the lungs)
Respiratory tract infection
Breast cancer
Cardiac arrest
Cervix disorder
Contusion (a type of hematoma of tissue in which capillaries)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Sudden cardiac death
Abdominal pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
International normalised ratio increased
Pyrexia (fever)
Renal disorder (kidney disease)
Renal tubular necrosis (death of kidney tubules)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)

What are the common drug interactions of Uloric and Vytorin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Agitation (state of anxiety or nervous excitement)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Lipase increased
Nephropathy (damage to or disease of a kidney)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Sudden cardiac death
Abdominal pain

60+:

Chest pain
Chronic kidney disease
Acute respiratory failure
Anaemia (lack of blood)
Atelectasis (partial or complete collapse of the lung)
Blood alkaline phosphatase increased
Blood creatinine increased
Blood glucose increased
Blood urea increased
Breast cancer

What are the existing conditions these people have? *

Cardiac Disorder: 11 people, 26.83%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 26.83%
Diabetes: 8 people, 19.51%
Thyroid Diseases: 7 people, 17.07%
High Blood Pressure: 7 people, 17.07%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 12.20%
Renal Disorder (kidney disease): 5 people, 12.20%
Bone Disorder: 5 people, 12.20%
Insomnia (sleeplessness): 5 people, 12.20%
Fluid Retention (an abnormal accumulation of fluid in the blood): 5 people, 12.20%

* Approximation only. Some reports may have incomplete information.

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