Ultane and Fentanyl citrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultane (sevoflurane) and Fentanyl citrate (fentanyl citrate). Common drug interactions include hyperthermia malignant among females and pulmonary oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Ultane and Fentanyl citrate. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Ultane?

Ultane has active ingredients of sevoflurane. eHealthMe is studying from 677 Ultane users. Check the latest studies of Ultane.

What is Fentanyl citrate?

Fentanyl citrate has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 21,294 Fentanyl citrate users. Check the latest studies of Fentanyl citrate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

18 people who take Ultane and Fentanyl citrate together, and have interactions are studied.

Ultane and Fentanyl citrate drug interactions.

What are the common drug interactions of Ultane and Fentanyl Citrate, by gender? *:

female:

Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
Bradycardia (abnormally slow heart action)
Cardiac arrest
Generalised oedema (swelling all over the body)
Haemorrhage (bleeding)
Hyperkalaemia (damage to or disease of the kidney)
Low cardiac output syndrome (decreased cardiac output)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Multi-organ failure (multisystem organ failure)
Ventricular fibrillation (abnormally irregular heart rhythm)

male:

Pulmonary oedema (fluid accumulation in the lungs)
Atelectasis (partial or complete collapse of the lung)
Ventricular extrasystoles (premature cardiac contraction)
Anaesthetic complication
Anaphylactic reaction (serious allergic reaction)
Blood carbon dioxide increased
Blood ph decreased
Death
Dyspnoea (difficult or laboured respiration)
Feeding tube complication

What are the common drug interactions of Ultane and Fentanyl Citrate, by age (0-1 to 60+)? *:

0-1:

Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

2-9:

Bradycardia (abnormally slow heart action)
Cardiac arrest
Generalised oedema (swelling all over the body)
Haemorrhage (bleeding)
Haemorrhagic diathesis (bleeding tendency)
Hypercapnia (too much smoke)
Hyperkalaemia (damage to or disease of the kidney)
Hyperthermia malignant (disease passed down through families that causes a fast rise in body temperature (fever) and severe muscle contractions)
Low cardiac output syndrome (decreased cardiac output)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

10-19:

Anaphylactic reaction (serious allergic reaction)
Death

20-29:

Blood carbon dioxide increased
Blood ph decreased
Dyspnoea (difficult or laboured respiration)
Po2 decreased
Pulmonary oedema (fluid accumulation in the lungs)
Sputum discoloured

30-39:

Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

40-49:

Atelectasis (partial or complete collapse of the lung)
Hypoventilation (too shallow or too slow breathing, which does not meet the needs of the body)
Respiratory depression (respiration has a rate below 12 breaths)
Respiratory muscle weakness
Sputum retention

50-59:

Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
Feeding tube complication
Haematoma (collection of blood outside the blood vessels)
Hypertension (high blood pressure)
Muscle necrosis (muscle cell damage)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Oedema (fluid collection in tissue)
Respiratory disorder (respiratory disease)

60+:

Pulmonary oedema (fluid accumulation in the lungs)
Delayed recovery from anaesthesia
Pyloric stenosis (narrowing of the passage between the stomach and the small intestine)
Respiratory depression (respiration has a rate below 12 breaths)
Respiratory muscle weakness
Sputum retention
Post procedural complication
Ventricular extrasystoles (premature cardiac contraction)
Anaesthetic complication
Atelectasis (partial or complete collapse of the lung)

What are the existing conditions these people have? *

General Anaesthesia: 4 people, 22.22%
Anaesthesia: 4 people, 22.22%
High Blood Pressure: 2 people, 11.11%
Post Procedural Oedema (excessive build-up of fluid in the body's tissues after procedure): 1 person, 5.56%
Lip And/or Oral Cavity Cancer (cancer of lip or mouth): 1 person, 5.56%
Diabetes Insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 1 person, 5.56%
Cardiac Disorder: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Ultane and Fentanyl citrate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously