Ultracet and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultracet (acetaminophen; tramadol hydrochloride) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include dizziness among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Ultracet and Macrobid. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Ultracet?

Ultracet has active ingredients of acetaminophen; tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 6,351 Ultracet users. Check the latest studies of Ultracet.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 31, 2026

39 people who take Ultracet and Macrobid together, and have interactions are studied.

Ultracet and Macrobid drug interactions.

What are the common drug interactions of Ultracet and Macrobid, by gender? *:

female:

Dizziness
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphemia (stammering or stuttering)
Excessive eye blinking (excessive blinking is dry eyes)
Gallbladder disorder
Haematuria (presence of blood in urine)
Hostility
Arthralgia (joint pain)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Fall

male:

Anxiety
Blood cholesterol increased
Dysstasia (difficulty in standing)
Hypokinesia (decreased bodily movement)
Limb discomfort (discomfort in leg)
Neutropenia (an abnormally low number of neutrophils)
Peripheral swelling
Platelet count decreased
Somnolence (a state of near-sleep, a strong desire for sleep)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Ultracet and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Fibromyalgia (a long-term condition which causes pain all over the body)
Mania (a state of abnormally elevated or irritable mood)
Neuropathy peripheral (surface nerve damage)
Renal failure (kidney dysfunction)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Chronic kidney disease

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Dependence
Drug abuse
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Eating disorder
Fall
Fatigue (feeling of tiredness)

50-59:

Fall
Gallbladder disorder
Injury
Insomnia (sleeplessness)
Joint effusion (presence of extra fluid in joint covering)
Muscle spasms (muscle contraction)
Myofascial pain syndrome (a painful condition that affects the muscles and the sheath of the tissue)
Osteoporosis (bones weak and more likely to break)
Panic reaction
Postoperative infection

60+:

Anxiety
Drug hypersensitivity
Blood glucose increased
Drooling (drop saliva uncontrollably from the mouth)
Dry mouth
Dysarthria (speech disorder)
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphemia (stammering or stuttering)
Erythema (redness of the skin)

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 35.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 30.77%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 25.64%
Depression: 9 people, 23.08%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 8 people, 20.51%
Insomnia (sleeplessness): 8 people, 20.51%
Stress And Anxiety: 7 people, 17.95%
Restless Leg Syndrome (a powerful urge to move your legs): 7 people, 17.95%
Hypertriglyceridaemia (excess of triglycerides in the blood): 6 people, 15.38%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 6 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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