Ultram and Anaprox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultram (tramadol hydrochloride) and Anaprox (naproxen sodium). Common drug interactions include anxiety among females and arteriosclerosis among males.

The phase IV clinical study analyzes what interactions people have when they take Ultram and Anaprox. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Anaprox?

Anaprox has active ingredients of naproxen sodium. eHealthMe is studying from 1,370 Anaprox users. Check the latest studies of Anaprox.

On Jul, 07, 2026

35 people who take Ultram and Anaprox together, and have interactions are studied.

What are the common drug interactions of Ultram and Anaprox, by gender? *:

female:

Anxiety
Arthropathy
Atrioventricular block complete (heart block complete)
Atrioventricular block first degree (heart block first degree)
Blood iron increased
Cachexia (loss of weight)
Cardiac murmur (an heart sound in valve abnormality)
Carotid bruit (sound heard over the carotid artery area during auscultation)
Cervical cyst (mucus-filled cyst on the surface of the cervix)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)

male:

Arteriosclerosis (thickening and hardening of arteries)
Abdominal distension
Irritable bowel syndrome
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nephrolithiasis (calculi in the kidneys)
Oedema peripheral (superficial swelling)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pulmonary oedema (fluid accumulation in the lungs)
Vertigo
Anaemia (lack of blood)

What are the common drug interactions of Ultram and Anaprox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anaemia (lack of blood)
Brain death
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Liver disorder (liver diseases)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Migraine (headache)
Renal failure acute (rapid kidney dysfunction)
Respiratory depression (respiration has a rate below 12 breaths)
Respiratory failure (inadequate gas exchange by the respiratory system)

30-39:

Alcoholism (problems with alcohol)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Death
Dependence
Drug effect decreased
Drug toxicity
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Migraine (headache)

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Aspartate aminotransferase increased
Asthenia (weakness)
Atrioventricular block second degree (heart block second degree)
Blood alkaline phosphatase increased
Blood bilirubin increased
Bronchial secretion retention
Cardiac disorder
Cardiac failure congestive
Cardioactive drug level above therapeutic

50-59:

Renal failure (kidney dysfunction)
Nausea (feeling of having an urge to vomit)
Arthralgia (joint pain)
Back pain
Blood pressure increased
Decreased appetite
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)

60+:

Anaemia (lack of blood)
Drug hypersensitivity
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Intussusception
Rectal haemorrhage (bleeding from anus)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 17.14%
Migraine (headache): 4 people, 11.43%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 8.57%
Gastric Disorder (disease of stomach): 3 people, 8.57%
Depression: 3 people, 8.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.57%
Stress And Anxiety: 2 people, 5.71%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 5.71%
Hypersensitivity: 2 people, 5.71%
High Blood Pressure: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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