Ultram and Hydrocodone bitartrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultram (tramadol hydrochloride) and Hydrocodone bitartrate (hydrocodone bitartrate). Common drug interactions include drug dependence among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Ultram and Hydrocodone bitartrate. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Hydrocodone bitartrate?

Hydrocodone bitartrate has active ingredients of hydrocodone bitartrate. It is often used in chronic pain. eHealthMe is studying from 5,380 Hydrocodone bitartrate users. Check the latest studies of Hydrocodone bitartrate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 03, 2026

15 people who take Ultram and Hydrocodone bitartrate together, and have interactions are studied.

Ultram and Hydrocodone bitartrate drug interactions.

What are the common drug interactions of Ultram and Hydrocodone Bitartrate, by gender? *:

female:

Drug dependence
Overdose
Anxiety
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Emotional distress
Abdominal discomfort
Abdominal pain upper
Apathy
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Constipation

male:

Drug dependence
Overdose
Chronic kidney disease
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Emotional distress
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Nightmare (unpleasant dream)
Substance abuse
Delusion (a false belief or opinion)

What are the common drug interactions of Ultram and Hydrocodone Bitartrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Drug dependence
Overdose
Abdominal discomfort
Abdominal pain upper
Apathy
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Constipation
Depressed mood
Hyperaesthesia
Lethargy (tiredness)

50-59:

Delusion (a false belief or opinion)
Drug dependence
Renal impairment (severely reduced kidney function)
Hyperhidrosis (abnormally increased sweating)
Hypopnoea (decrease in the breathing rate)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Overdose
Blood glucose decreased
Chronic kidney disease
Impaired gastric emptying

60+:

n/a

What are the existing conditions these people have? *

Sleep Disorder: 2 people, 13.33%
Back Injury: 2 people, 13.33%
Spinal Osteoarthritis (joint cartilage loss in spine): 1 person, 6.67%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 6.67%
Pain In Extremity: 1 person, 6.67%
Infection: 1 person, 6.67%
Immunodeficiency: 1 person, 6.67%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 1 person, 6.67%
Hiv Infection: 1 person, 6.67%
Headache (pain in head): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and Hydrocodone bitartrate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously