Ultram and Isordil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultram (tramadol hydrochloride) and Isordil (isosorbide dinitrate). Common drug interactions include visual impairment among females and hypoglycaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Ultram and Isordil. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Isordil?

Isordil has active ingredients of isosorbide dinitrate. eHealthMe is studying from 3,022 Isordil users. Check the latest studies of Isordil.

On Jul, 15, 2026

83 people who take Ultram and Isordil together, and have interactions are studied.

What are the common drug interactions of Ultram and Isordil, by gender? *:

female:

Visual impairment
Constipation
Hypoaesthesia (reduced sense of touch or sensation)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Abdominal pain
Anaphylactic reaction (serious allergic reaction)
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)

male:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Syncope (loss of consciousness with an inability to maintain postural tone)
Renal failure acute (rapid kidney dysfunction)
Activated partial thromboplastin time prolonged
Acute respiratory failure
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Balance disorder

What are the common drug interactions of Ultram and Isordil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac failure congestive
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Gastroenteritis (inflammation of stomach and intestine)
Haematuria (presence of blood in urine)
Headache (pain in head)

50-59:

Abdominal pain upper
Acute respiratory failure
Anaemia (lack of blood)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood pressure decreased
Cardiac failure congestive
Cardiac valve disease (heart valve disease)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Endocarditis (inflammation in heart muscle)

60+:

Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Appetite disorder (abnormal eating habits)
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chills (felling of cold)
Constipation
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphoria (generalized dissatisfaction with life)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Dizziness: 38 people, 45.78%
Chest Pain: 7 people, 8.43%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 8.43%
Nausea (feeling of having an urge to vomit): 6 people, 7.23%
Constipation: 6 people, 7.23%
Sleep Disorder: 5 people, 6.02%
High Blood Pressure: 5 people, 6.02%
High Blood Cholesterol: 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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