Ultram and Nyquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultram (tramadol hydrochloride) and Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine). Common drug interactions include coagulopathy among females and abscess limb among males.

The phase IV clinical study analyzes what interactions people have when they take Ultram and Nyquil. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

On Jul, 18, 2026

12 people who take Ultram and Nyquil together, and have interactions are studied.

What are the common drug interactions of Ultram and Nyquil, by gender? *:

female:

Coagulopathy (blood's ability to clot is impaired)
Leukocytosis (increased white blood cells)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Overdose
Pancreatitis (inflammation of pancreas)
Renal failure acute (rapid kidney dysfunction)
Thrombocytopenia (decrease of platelets in blood)
Vascular insufficiency
Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Arthralgia (joint pain)

male:

Abscess limb (limb infection)
Anal abscess
Death
Drug screen positive
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Perirectal abscess
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Ultram and Nyquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Arthralgia (joint pain)
Bankruptcy
Binge eating (pattern of disordered eating which consists of episodes of uncontrollable eating)
Blunted affect (lack of emotional reactivity)
Compulsive sexual behaviour (unable to manage his/her sexual behaviour)
Emotional distress
Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)

40-49:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Overdose
Pancreatitis (inflammation of pancreas)
Renal failure acute (rapid kidney dysfunction)
Thrombocytopenia (decrease of platelets in blood)
Vascular insufficiency
Abscess limb (limb infection)
Anal abscess
Perirectal abscess
Scrotal abscess (pus in scrotum)

50-59:

Drug screen positive
Dyskinesia (abnormality or impairment of voluntary movement)
Loss of consciousness
Migraine (headache)
Rib fracture

60+:

Death
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 50.00%
Stress And Anxiety: 2 people, 16.67%
Weight Decreased: 1 person, 8.33%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 8.33%
Back Pain: 1 person, 8.33%
Bipolar Disorder (mood disorder): 1 person, 8.33%
Chest Pain: 1 person, 8.33%
Facial Pain: 1 person, 8.33%
Hypotension (abnormally low blood pressure): 1 person, 8.33%
Infection: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and Nyquil?

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