Ultram and Pegasys drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultram (tramadol hydrochloride) and Pegasys (peginterferon alfa 2a). Common drug interactions include weight decreased among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Ultram and Pegasys. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Pegasys?

Pegasys has active ingredients of peginterferon alfa 2a. It is often used in hepatitis c. eHealthMe is studying from 57,446 Pegasys users. Check the latest studies of Pegasys.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

56 people who take Ultram and Pegasys together, and have interactions are studied.

What are the common drug interactions of Ultram and Pegasys, by gender? *:

female:

Weight decreased
Alopecia (absence of hair from areas of the body)
Chills (felling of cold)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Haemoglobin decreased
Pain in extremity
Platelet count decreased
Skin exfoliation (removal of the oldest dead skin cells)

male:

Nausea (feeling of having an urge to vomit)
Chills (felling of cold)
Memory impairment
Shoulder pain
Blood glucose increased
Dyspnoea (difficult or laboured respiration)
Myalgia (muscle pain)
Abdominal pain
Depression
Dysgeusia (disorder of the sense of taste)

What are the common drug interactions of Ultram and Pegasys, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Asthenia (weakness)
Chest discomfort
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diarrhoea
Faeces discoloured
Fall
Hunger
Nausea (feeling of having an urge to vomit)
Pallor

30-39:

Abdominal pain
Blood calcium decreased
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Heart rate increased
Infusion site reaction
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Insomnia (sleeplessness)
Neuropathy peripheral (surface nerve damage)

40-49:

Nausea (feeling of having an urge to vomit)
Dizziness
Blood pressure decreased
Confusional state
Heart rate decreased
Shoulder pain
Fatigue (feeling of tiredness)
Headache (pain in head)
Anxiety
Bone pain

50-59:

Urinary tract infection
Vaginal haemorrhage (vaginal bleeding)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Insomnia (sleeplessness)
Abdominal pain
Chills (felling of cold)
Confusional state
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)

60+:

Ageusia (loss of taste functions of the tongue)
Anaemia (lack of blood)
Pruritus (severe itching of the skin)
Rash
Sensory disturbance (sense disturbance)
Skin ulcer
Weight increased
Anxiety
Drug ineffective
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Depression: 8 people, 14.29%
High Blood Pressure: 7 people, 12.50%
Anaesthesia: 6 people, 10.71%
Primary Myelofibrosis (primary disorder of the bone marrow): 5 people, 8.93%
Headache (pain in head): 5 people, 8.93%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 3 people, 5.36%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 5.36%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.36%
Blood Iron Decreased: 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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