Ultram and Pentasa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultram (tramadol hydrochloride) and Pentasa (mesalamine). Common drug interactions include pharyngolaryngeal pain among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Ultram and Pentasa. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

44 people who take Ultram and Pentasa together, and have interactions are studied.

What are the common drug interactions of Ultram and Pentasa, by gender? *:

female:

Pharyngolaryngeal pain
Rigors (an episode of shaking or exaggerated shivering)
Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum)
Sinusitis (inflammation of sinus)
Tenosynovitis (inflammation of the fluid-filled sheath (called the synovium) that surrounds a tendon)
Throat tightness
Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop)
Abdominal pain
Abscess intestinal (collections of pus-intestinal)
Activities of daily living impaired

male:

Renal failure (kidney dysfunction)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Renal cyst (kidney cyst)
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Weight increased
Arthralgia (joint pain)
Injury
Oedema peripheral (superficial swelling)
Abdominal pain lower
Antinuclear antibody positive

What are the common drug interactions of Ultram and Pentasa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Rash
Confusional state
Headache (pain in head)
Migraine (headache)
Oropharyngeal pain
Pain in extremity
Pharyngolaryngeal pain
Tremor (trembling or shaking movements in one or more parts of your body)

20-29:

Blood urine present

30-39:

Abscess intestinal (collections of pus-intestinal)
Colonic fistula (abnormal passage to other organ from colon)
Constipation
Diarrhoea
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Nausea (feeling of having an urge to vomit)
Rectal haemorrhage (bleeding from anus)
Small intestinal obstruction (blockage in small intestine)
Abdominal pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)

40-49:

Death
Abdominal pain upper
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Constipation
Diarrhoea
Dyspepsia (indigestion)
Influenza
Nausea (feeling of having an urge to vomit)
Peripheral swelling
Pyrexia (fever)

50-59:

Immune system disorder
Influenza
Nasopharyngitis (inflammation of the nasopharynx)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Platelet count decreased
Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
Pruritus generalised (generalized itching)
Pyrexia (fever)
Rash
Renal failure (kidney dysfunction)

60+:

Dyspnoea (difficult or laboured respiration)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Pleural effusion (water on the lungs)
Renal cyst (kidney cyst)
Renal failure (kidney dysfunction)
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Weight increased
Arthritis infective (purulent invasion of a joint by an infectious agent which produces arthritis)
Injury
Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 8 people, 18.18%
Depression: 7 people, 15.91%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 11.36%
Pyoderma Gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance): 5 people, 11.36%
Muscle Spasms (muscle contraction): 5 people, 11.36%
Insomnia (sleeplessness): 5 people, 11.36%
Stress And Anxiety: 5 people, 11.36%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 11.36%
Abdominal Pain: 4 people, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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