Ultram and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultram (tramadol hydrochloride) and Savella (milnacipran hydrochloride). Common drug interactions include fatigue among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Ultram and Savella. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

On Jul, 12, 2026

88 people who take Ultram and Savella together, and have interactions are studied.

What are the common drug interactions of Ultram and Savella, by gender? *:

female:

Fatigue (feeling of tiredness)
Abdominal pain
Arthralgia (joint pain)
Insomnia (sleeplessness)
Headache (pain in head)
Suicidal ideation
Migraine (headache)
Chronic kidney disease
Hyperhidrosis (abnormally increased sweating)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Drug ineffective
Hypersensitivity
Urinary retention (the inability to completely or partially empty the bladder)
Disturbance in attention
Fatigue (feeling of tiredness)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Agitation (state of anxiety or nervous excitement)

What are the common drug interactions of Ultram and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Suffocation feeling

20-29:

Rash

30-39:

Arthralgia (joint pain)
Nephrolithiasis (calculi in the kidneys)
Balance disorder
Blood pressure increased
Chronic kidney disease
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug ineffective
Ear disorder
Headache (pain in head)
Joint range of motion decreased (disease of joint movement)

40-49:

Abdominal pain
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Alanine aminotransferase increased
Anaemia (lack of blood)
Anaemia vitamin b12 deficiency
Anger
Aphagia (inability or refusal to swallow)
Behcet's syndrome (involves inflammation of the blood vessels)
Blood chloride decreased

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Infection
Memory impairment
Mood altered (changes in mood)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Night sweats (sweating in night)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Paranasal sinus hypersecretion

60+:

Chills (felling of cold)
Suicidal ideation
Agitation (state of anxiety or nervous excitement)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Anxiety
Arthropathy
Asthenia (weakness)
Bladder disorder

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 15.91%
Depression: 12 people, 13.64%
Nausea (feeling of having an urge to vomit): 11 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 11.36%
Stress And Anxiety: 8 people, 9.09%
High Blood Pressure: 8 people, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 7.95%
Nausea And Vomiting: 6 people, 6.82%
Muscle Spasms (muscle contraction): 6 people, 6.82%
Migraine (headache): 6 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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