Ultram and Zebeta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ultram (tramadol hydrochloride) and Zebeta (bisoprolol fumarate). Common drug interactions include chills among females and upper gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Ultram and Zebeta. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Zebeta?

Zebeta has active ingredients of bisoprolol fumarate. It is often used in high blood pressure. eHealthMe is studying from 1,734 Zebeta users. Check the latest studies of Zebeta.

On Jan, 04, 2026

28 people who take Ultram and Zebeta together, and have interactions are studied.

What are the common drug interactions of Ultram and Zebeta, by gender? *:

female:

Chills (felling of cold)
Chronic kidney disease
Exostosis (formation of new bone on the surface of a bone)
Eye pain
Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
Pyrexia (fever)
Rash

male:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Rectal haemorrhage (bleeding from anus)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block first degree (heart block first degree)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood glucose decreased

What are the common drug interactions of Ultram and Zebeta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood cholesterol increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Glaucoma (increased fluid pressure in the eye with vision loss)
Neuropathy peripheral (surface nerve damage)
Purpura senile (skin condition in which areas of the skin develop a purplish or reddish-brown appearance due to bleeding of small blood vessels underneath)
Renal failure (kidney dysfunction)
Resorption bone increased
Tarsal tunnel syndrome (a condition that is caused by compression of the tibial nerve or its associated branches as the nerve)

40-49:

n/a

50-59:

Fibrin d dimer increased
Oxygen saturation decreased
Pulmonary congestion (congestion in the lungs)
Transaminases increased
Breast cancer
Cardiomegaly (increased size of heart than normal)
Lymphadenopathy (disease or enlargement of lymph nodes)
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Pneumonia

60+:

Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Rectal haemorrhage (bleeding from anus)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Loss of consciousness
Neuropathy peripheral (surface nerve damage)
Retching (strong involuntary effort to vomit)
Thyroid disorder (thyroid diseases)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 28.57%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 25.00%
Diabetes: 5 people, 17.86%
High Blood Cholesterol: 5 people, 17.86%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 14.29%
Gout (uric acid crystals building up in the body): 4 people, 14.29%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 14.29%
Cardiac Failure Congestive: 4 people, 14.29%
Cardiac Disorder: 4 people, 14.29%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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