Unasyn and Meropenem drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Unasyn (ampicillin sodium; sulbactam sodium) and Meropenem (meropenem). Common drug interactions include hyperkalaemia among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Unasyn and Meropenem. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Unasyn?

Unasyn has active ingredients of ampicillin sodium; sulbactam sodium. eHealthMe is studying from 4,474 Unasyn users. Check the latest studies of Unasyn.

What is Meropenem?

Meropenem has active ingredients of meropenem. eHealthMe is studying from 33,295 Meropenem users. Check the latest studies of Meropenem.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

84 people who take Unasyn and Meropenem together, and have interactions are studied.

What are the common drug interactions of Unasyn and Meropenem, by gender? *:

female:

Hyperkalaemia (damage to or disease of the kidney)
White blood cell count decreased
Renal failure acute (rapid kidney dysfunction)
Interstitial lung disease
Platelet count decreased
Rash
Blood urea increased
Constipation
Diarrhoea
Fluid retention (an abnormal accumulation of fluid in the blood)

male:

Renal failure (kidney dysfunction)
Cellulitis (infection under the skin)
Anaemia (lack of blood)
Respiratory failure (inadequate gas exchange by the respiratory system)
Bacteraemia (presence of bacteria in the blood)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Infection
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Unasyn and Meropenem, by age (0-1 to 60+)? *:

0-1:

Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Heart rate increased
Rash
Rash neonatal (skin rash affecting healthy newborn babies)

2-9:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Pyrexia (fever)
White blood cell disorder

10-19:

Pneumonia
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Disturbance in attention
Dizziness
Fear of disease
Infective tenosynovitis (infective inflammation of a tendon sheath)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Memory impairment
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

20-29:

Platelet count decreased
White blood cell count decreased
Anaemia (lack of blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)
Interstitial lung disease
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema (fluid collection in tissue)
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)

30-39:

Cellulitis (infection under the skin)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Febrile neutropenia (fever with reduced white blood cells)
Fungal infection
Renal failure (kidney dysfunction)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Cholecystitis acute (rapid infection of gallbladder)
Epistaxis (bleed from the nose)
Hyperthyroidism (over activity of the thyroid gland)
Post procedural haemorrhage (post procedural bleeding)

40-49:

C-reactive protein increased
Eosinophil count increased
Full blood count increased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Hypotension (abnormally low blood pressure)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

Dizziness
Drug hypersensitivity
Encephalopathy (functioning of the brain is affected by some agent or condition)
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Infusion related reaction
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Pneumonia
Aortitis (inflammation of the aortic wall)
Sepsis (a severe blood infection that can lead to organ failure and death)
Nausea (feeling of having an urge to vomit)
Vomiting
Blood urea increased
Constipation
Diarrhoea
Fluid retention (an abnormal accumulation of fluid in the blood)
Haemorrhage subcutaneous (bleeding from skin)

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 16.67%
Pneumonia: 13 people, 15.48%
Pain: 9 people, 10.71%
Dehydration (dryness resulting from the removal of water): 8 people, 9.52%
Gastric Ulcer (stomach ulcer): 7 people, 8.33%
Fungal Infection: 7 people, 8.33%
Fever: 7 people, 8.33%
Constipation: 7 people, 8.33%
Osteoporosis (bones weak and more likely to break): 6 people, 7.14%
Oedema (fluid collection in tissue): 6 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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