Coversyl plus and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Coversyl plus (perindopril arginine; indapamide hemihydrate), especially for people who are female, 60+ old, also take Inflectra, and have High blood pressure.

The phase IV clinical study analyzes which people have Malaise when taking Coversyl plus. It is created by eHealthMe based on reports of 354 people who have side effects when taking Coversyl plus from the FDA, and is updated regularly.

What is Coversyl plus?

Coversyl plus has active ingredients of perindopril arginine; indapamide hemihydrate. eHealthMe is studying from 412 Coversyl plus users. Check the latest studies of Coversyl plus.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,488 drugs and 5,129 conditions by eHealthMe. Check the latest studies of Malaise.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

354 people reported to have side effects when taking Coversyl plus.
Among them, 33 people (9.32%) have Malaise.

Among these 33 people:

What is the gender of people who have Malaise when taking Coversyl plus? *

female: 58.33 %
male: 41.67 %

What is the age of people who have Malaise when taking Coversyl plus? *

What are other drugs people take besides Coversyl plus? *

What are other side effects people have besides Malaise? *

Heart Rate Increased: 15 people, 45.45%
High Blood Pressure: 14 people, 42.42%
Joint Pain: 12 people, 36.36%
Hypotension (abnormally low blood pressure): 11 people, 33.33%
Cough: 11 people, 33.33%
Nausea (feeling of having an urge to vomit): 10 people, 30.30%
Nasopharyngitis (inflammation of the nasopharynx): 10 people, 30.30%
Diarrhea: 10 people, 30.30%
Nausea And Vomiting: 10 people, 30.30%
Fever: 9 people, 27.27%

What are the existing conditions these people have? *

High Blood Pressure: 17 people, 51.52%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 11 people, 33.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 27.27%
Fluid Retention (an abnormal accumulation of fluid in the blood): 8 people, 24.24%
Carcinoid Tumor: 4 people, 12.12%
Abdominal Discomfort: 3 people, 9.09%
Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 3 people, 9.09%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 9.09%
Asthma: 3 people, 9.09%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Coversyl plus and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Coversyl plus:

Coversyl plus (412 reports)

Malaise treatments and more:

Malaise (529,933 reports)

How severe was Malaise and when was it recovered:

Malaise in Coversyl plus

Expand to all the drugs that have ingredients of perindopril arginine; indapamide hemihydrate:

Malaise and drugs with ingredients of perindopril arginine; indapamide hemihydrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Coversyl plus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,488 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,129 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on perindopril arginine; indapamide hemihydrate (the active ingredients of Coversyl plus) and Coversyl plus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.