Unithroid and Spironolactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Unithroid (levothyroxine sodium) and Spironolactone (spironolactone). Common drug interactions include constipation among females and dysgraphia among males.

The phase IV clinical study analyzes what interactions people have when they take Unithroid and Spironolactone. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Unithroid?

Unithroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 890 Unithroid users. Check the latest studies of Unithroid.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,946 Spironolactone users. Check the latest studies of Spironolactone.

On Apr, 30, 2026

19 people who take Unithroid and Spironolactone together, and have interactions are studied.

Unithroid and Spironolactone drug interactions.

What are the common drug interactions of Unithroid and Spironolactone, by gender? *:

female:

Constipation
Muscle spasms (muscle contraction)
Nasopharyngitis (inflammation of the nasopharynx)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Yellow skin
Abdominal distension
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthma
Back pain
Blood glucose decreased

male:

Dysgraphia (impaired ability to learn to write)
Malaise (a feeling of general discomfort or uneasiness)
Tremor (trembling or shaking movements in one or more parts of your body)
Body height decreased

What are the common drug interactions of Unithroid and Spironolactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dizziness
Dysmenorrhoea (painful menstruation)
Nausea (feeling of having an urge to vomit)

30-39:

n/a

40-49:

Abdominal distension
Back pain
Constipation

50-59:

Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Constipation
Depression
Diarrhoea
Dizziness

60+:

Dysgraphia (impaired ability to learn to write)
Malaise (a feeling of general discomfort or uneasiness)
Vision blurred
Tremor (trembling or shaking movements in one or more parts of your body)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Blood glucose increased
Body height decreased
Colitis ulcerative (inflammation of colon with ulcer)
Death
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Amyloidosis (a tumour within which amyloid is produced): 2 people, 10.53%
Upper Gastrointestinal Haemorrhage (upper gastrointestinal bleeding): 2 people, 10.53%
Cardiac Amyloidosis (protein deposition in heart): 2 people, 10.53%
Cardiac Disorder: 2 people, 10.53%
Diabetes: 2 people, 10.53%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 10.53%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 2 people, 10.53%
Cardiac Failure: 1 person, 5.26%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 5.26%
Chronic Thyroiditis (long lasting inflammation of thyroid gland): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Unithroid and Spironolactone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously