Ursodiol and Mepron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ursodiol (ursodiol) and Mepron (atovaquone). Common drug interactions include acute graft versus host disease in skin among females and arthropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Ursodiol and Mepron. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Ursodiol?

Ursodiol has active ingredients of ursodiol. It is often used in primary biliary cirrhosis. eHealthMe is studying from 19,061 Ursodiol users. Check the latest studies of Ursodiol.

What is Mepron?

Mepron has active ingredients of atovaquone. It is often used in babesiosis. eHealthMe is studying from 2,091 Mepron users. Check the latest studies of Mepron.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

43 people who take Ursodiol and Mepron together, and have interactions are studied.

What are the common drug interactions of Ursodiol and Mepron, by gender? *:

female:

Acute graft versus host disease in skin (acute complication on skin following an allogeneic tissue/blood transplant)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Amylase increased
Atelectasis (partial or complete collapse of the lung)
Blood lactate dehydrogenase increased
Chronic myeloid leukaemia transformation (cancer of blood forming cells spreads to blood cells)
Culture stool positive
Cytomegalovirus infection
Disease progression
Disseminated intravascular coagulation (systemic activation of blood coagulation)

male:

Arthropathy
Back pain
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Blood alkaline phosphatase increased
Blood lactate dehydrogenase increased
Blood potassium increased
Blood urine present
Chest pain
Constipation
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)

What are the common drug interactions of Ursodiol and Mepron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Pulmonary arterial pressure increased
Pyrexia (fever)
Respiratory distress (difficulty in breathing)
Splenomegaly (enlargement of spleen)
Viral upper respiratory tract infection
Vomiting
Adverse drug reaction
Back pain
Blood potassium increased
Chest pain

10-19:

Vomiting

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pulmonary embolism (blockage of the main artery of the lung)

30-39:

Venoocclusive liver disease (small veins in the liver are obstructed)
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Feeling hot

40-49:

Arthropathy
Lymphoma (cancer that begins in immune system cells)
Disease complication

50-59:

Blood pressure increased
Thrombocytopenia (decrease of platelets in blood)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Cough
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Dysplasia (enlargement of an organ or tissue)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Immunosuppression
Infection susceptibility increased

60+:

Diarrhoea
Abdominal discomfort
Joint swelling
Nausea (feeling of having an urge to vomit)
Oropharyngeal discomfort (pain or irritation of oropharynx)
Peripheral swelling
Platelet count decreased
Swelling face
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 7 people, 16.28%
Stress And Anxiety: 3 people, 6.98%
Rashes (redness): 3 people, 6.98%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 6.98%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 6.98%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 6.98%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 6.98%
Abdominal Pain: 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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