Valacyclovir hydrochloride and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valacyclovir hydrochloride (valacyclovir hydrochloride) and Actonel (risedronate sodium). Common drug interactions include osteonecrosis of jaw among females and interstitial lung disease among males.

The phase IV clinical study analyzes what interactions people have when they take Valacyclovir hydrochloride and Actonel. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Valacyclovir hydrochloride?

Valacyclovir hydrochloride has active ingredients of valacyclovir hydrochloride. It is often used in herpes zoster. eHealthMe is studying from 12,929 Valacyclovir hydrochloride users. Check the latest studies of Valacyclovir hydrochloride.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 14, 2026

40 people who take Valacyclovir hydrochloride and Actonel together, and have interactions are studied.

Valacyclovir hydrochloride and Actonel drug interactions.

What are the common drug interactions of Valacyclovir Hydrochloride and Actonel, by gender? *:

female:

Osteonecrosis of jaw (death of bone of jaw)
Oral herpes (viral infection of mouth)
Periodontitis (inflammation of the tissue around the teeth)
Gastroenteritis (inflammation of stomach and intestine)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Necrosis (the death of body tissue)
Gingival ulceration (ulcer on gums)
Oral pain
Pain in jaw
C-reactive protein increased

male:

Interstitial lung disease
Blood pressure increased
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Escherichia sepsis (bacterial infection by escherichia coli)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Infusion related reaction
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Septic shock (shock due to blood infection)
Thrombotic thrombocytopenic purpura (a rare blood disorder characterized by clotting in small blood vessels of the body)
Glaucoma (increased fluid pressure in the eye with vision loss)

What are the common drug interactions of Valacyclovir Hydrochloride and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Renal impairment (severely reduced kidney function)
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Escherichia sepsis (bacterial infection by escherichia coli)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Septic shock (shock due to blood infection)
Thrombotic thrombocytopenic purpura (a rare blood disorder characterized by clotting in small blood vessels of the body)

60+:

Oral herpes (viral infection of mouth)
Osteonecrosis of jaw (death of bone of jaw)
C-reactive protein increased
Confusional state
Dyspnoea (difficult or laboured respiration)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Partial seizures (seizures which affect only a part of the brain at onset)
Hepatic enzyme increased
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Loss of consciousness

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 15 people, 37.50%
High Blood Pressure: 14 people, 35.00%
Oral Herpes (viral infection of mouth): 12 people, 30.00%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 11 people, 27.50%
Headache (pain in head): 4 people, 10.00%
Genital Herpes (herpes infection of genital): 4 people, 10.00%
Depression: 4 people, 10.00%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 10.00%
Vasculitis Necrotising (inflammation and damage to blood vessels): 2 people, 5.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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