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Valacyclovir and Naprosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valacyclovir (valacyclovir hydrochloride) and Naprosyn (naproxen). Common drug interactions include thrombocytopenia among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Valacyclovir and Naprosyn. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

On Aug, 01, 2026

61 people who take Valacyclovir and Naprosyn together, and have interactions are studied.

Valacyclovir and Naprosyn drug interactions.

What are the common drug interactions of Valacyclovir and Naprosyn, by gender? *:

female:

  1. Thrombocytopenia (decrease of platelets in blood)
  2. Tinnitus (a ringing in the ears)
  3. Tympanic membrane disorder (disease of ear drum)
  4. Uterine haemorrhage (uterine bleeding)
  5. Fatigue (feeling of tiredness)
  6. Asthenia (weakness)
  7. Nausea (feeling of having an urge to vomit)
  8. Renal failure chronic (long lasting kidney dysfunction)
  9. Upper respiratory tract infection
  10. Chills (felling of cold)

male:

  1. Headache (pain in head)
  2. Muscle strain (an injury to a muscle in which the muscle fibres tear)
  3. Migraine (headache)
  4. Prostate infection
  5. Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
  6. Cyst (a closed sac)
  7. Dermal cyst
  8. Hypersensitivity
  9. Staphylococcal skin infection (skin infection by an infection with staphylococcus bacteria)
  10. Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

What are the common drug interactions of Valacyclovir and Naprosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Diarrhoea
  2. Fatigue (feeling of tiredness)
  3. Asthenia (weakness)
  4. Chorea (abnormal involuntary movement disorder)
  5. Decreased activity
  6. Decreased appetite
  7. Decreased eye contact
  8. Gastrointestinal motility disorder (abnormal intestinal contractions)
  9. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  10. Sluggishness (lacking alertness)

20-29:

n/a

30-39:

  1. Chronic kidney disease
  2. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

40-49:

  1. Anxiety
  2. Aphonia (inability to produce voice)
  3. Apnoea (suspension of external breathing)
  4. Blood folate increased
  5. Blood sodium increased
  6. Carbon dioxide decreased
  7. Constipation
  8. Cough
  9. Depression
  10. Dysuria (painful or difficult urination)

50-59:

  1. Thrombocytopenia (decrease of platelets in blood)
  2. Tinnitus (a ringing in the ears)
  3. Tympanic membrane disorder (disease of ear drum)
  4. Uterine haemorrhage (uterine bleeding)
  5. Renal failure chronic (long lasting kidney dysfunction)
  6. Upper respiratory tract infection
  7. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
  8. Urinary tract infection
  9. Gastric ulcer (stomach ulcer)
  10. Haematuria (presence of blood in urine)

60+:

  1. Cough
  2. Gastrointestinal infection (infection of stomach and intestine)
  3. Hypersensitivity
  4. Migraine (headache)
  5. Prostate infection
  6. Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
  7. Cyst (a closed sac)
  8. Dermal cyst
  9. Staphylococcal skin infection (skin infection by an infection with staphylococcus bacteria)
  10. Pneumonia

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 12 people, 19.67%
  2. Immunodeficiency Common Variable: 10 people, 16.39%
  3. Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 8 people, 13.11%
  4. Osteomyelitis (infection of bone): 8 people, 13.11%
  5. Menopause (end of monthly cycles in women): 8 people, 13.11%
  6. Anaemia (lack of blood): 8 people, 13.11%
  7. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 8.20%
  8. Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir and Naprosyn?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Valacyclovir and Naprosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Naprosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Valacyclovir and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Naprosyn and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride and naproxen (the active ingredients of Valacyclovir and Naprosyn, respectively), and Valacyclovir and Naprosyn (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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