Valium and Estraderm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valium (diazepam) and Estraderm (estradiol). Common drug interactions include diabetes mellitus among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Valium and Estraderm. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Valium?

Valium has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 48,647 Valium users. Check the latest studies of Valium.

What is Estraderm?

Estraderm has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,441 Estraderm users. Check the latest studies of Estraderm.

On Jul, 22, 2026

62 people who take Valium and Estraderm together, and have interactions are studied.

What are the common drug interactions of Valium and Estraderm, by gender? *:

female:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic nephropathy (diabetic kidney disease)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Ear disorder
Foot fracture
Hyperlipidaemia (presence of excess lipids in the blood)
Incontinence (lack of moderation or self-control)
Injury
Intervertebral disc operation
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)

male:

Abdominal distension
Abdominal pain
Breast mass
Cardiac disorder
Cardiac valve disease (heart valve disease)
Cutis laxa (connective tissue disorder in which the skin lacks elasticity and hangs in loose folds)
Depression
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dyspepsia (indigestion)
Face injury

What are the common drug interactions of Valium and Estraderm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Palpitations (feelings or sensations that your heart is pounding or racing)
Recurrent cancer (repeated cancer)
Thyroid cancer
Uterine cancer

40-49:

Depression
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Nervousness
Weight decreased
Cough
Diarrhoea
Drug dependence
Insomnia (sleeplessness)

50-59:

Breast microcalcification (deposits of calcium that can be seen on a mammogram of the breast)
Breast pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carotid artery disease
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chest pain
Chronic fatigue syndrome (disorder that causes extreme fatigue)
Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

60+:

Breast cancer
Insomnia (sleeplessness)
Ventricular extrasystoles (premature cardiac contraction)
Asthenia (weakness)
Benign neoplasm of thyroid gland (benign (non-cancerous) tumours of the thyroid gland)
Bone density decreased
Breast cancer female
Breast fibrosis (the thickening and scarring of connective tissue, usually as a result of injury in breast)
Breast hyperplasia (accumulation of abnormal cells in a breast duct)
Breast mass

What are the existing conditions these people have? *

Pain: 14 people, 22.58%
Menopause (end of monthly cycles in women): 12 people, 19.35%
Type 2 Diabetes: 9 people, 14.52%
Menopausal Symptoms: 9 people, 14.52%
Depression: 8 people, 12.90%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 11.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.68%
High Blood Pressure: 5 people, 8.06%
Insomnia (sleeplessness): 4 people, 6.45%
High Blood Cholesterol: 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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