Valium and Invega drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valium (diazepam) and Invega (paliperidone). Common drug interactions include abdominal pain among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Valium and Invega. It is created by eHealthMe based on reports of 58 people who take the same drugs from the FDA, and is updated regularly.

What is Valium?

Valium has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 48,647 Valium users. Check the latest studies of Valium.

What is Invega?

Invega has active ingredients of paliperidone. It is often used in bipolar disorder. eHealthMe is studying from 32,353 Invega users. Check the latest studies of Invega.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

58 people who take Valium and Invega together, and have interactions are studied.

What are the common drug interactions of Valium and Invega, by gender? *:

female:

Abdominal pain
Blood glucose fluctuation
Chest discomfort
Eye haemorrhage (bleeding in the eye)
Fall
Fatigue (feeling of tiredness)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Injection site haemorrhage (bleeding from injection site)
Joint dislocation (a joint position is changed from normal position)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Insomnia (sleeplessness)
Suicidal ideation
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed mood
Dyslipidaemia (abnormal amount of lipids)
Dystonia (abnormal muscle tone)
Electrolyte imbalance
Emotional disorder
Eye disorder

What are the common drug interactions of Valium and Invega, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Muscular weakness (muscle weakness)
Headache (pain in head)
Myalgia (muscle pain)
Psychotic disorder
Erectile dysfunction
Tremor (trembling or shaking movements in one or more parts of your body)
Anosognosia (ignorance of the presence of disease)
Catatonia (unresponsive to external stimuli)
Hospitalisation
Malaise (a feeling of general discomfort or uneasiness)

30-39:

Injection site discomfort
Injection site pain
Injection site swelling
Weight decreased
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Blood urine present
Menstruation delayed (late menstruation cycle)
Urinary tract infection
Blood glucose fluctuation
Depressed mood

40-49:

Suicidal ideation
Suicide attempt
Weight increased
Dystonia (abnormal muscle tone)
Adverse event
Tinnitus (a ringing in the ears)
Abnormal behaviour
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Cellulitis (infection under the skin)
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)

50-59:

Abdominal pain
Abdominal pain upper
Hand fracture
Defaecation urgency (a sudden compelling urge to defecate)
Gastritis (inflammation of stomach)
Oedema peripheral (superficial swelling)
Adverse drug reaction
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Fatigue (feeling of tiredness)

60+:

Blood magnesium decreased
Blood potassium decreased
Blood sodium decreased
Sepsis (a severe blood infection that can lead to organ failure and death)
Small cell lung cancer (small cell cancer tumour of lung)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 14 people, 24.14%
Psychotic Disorder: 7 people, 12.07%
Pain: 7 people, 12.07%
Depression: 6 people, 10.34%
Constipation: 6 people, 10.34%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 6 people, 10.34%
Agitation (state of anxiety or nervous excitement): 5 people, 8.62%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 6.90%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 3 people, 5.17%
High Blood Cholesterol: 3 people, 5.17%

* Approximation only. Some reports may have incomplete information.

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