Valium and Motrin ib drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valium (diazepam) and Motrin ib (ibuprofen). Common drug interactions include paranoia among females and hepatic enzyme increased among males.

The phase IV clinical study analyzes what interactions people have when they take Valium and Motrin ib. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Valium?

Valium has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 48,647 Valium users. Check the latest studies of Valium.

What is Motrin ib?

Motrin ib has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 3,772 Motrin ib users. Check the latest studies of Motrin ib.



On Jul, 16, 2026

33 people who take Valium and Motrin ib together, and have interactions are studied.

Valium and Motrin ib drug interactions.

What are the common drug interactions of Valium and Motrin Ib, by gender? *:

female:

  1. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
  2. Fibromyalgia (a long-term condition which causes pain all over the body)
  3. Back pain
  4. Balance disorder
  5. Blood pressure increased
  6. Diplopia (double vision)
  7. Inappropriate affect
  8. Malaise (a feeling of general discomfort or uneasiness)
  9. Nervousness
  10. Snoring

male:

  1. Hepatic enzyme increased
  2. Hypoaesthesia (reduced sense of touch or sensation)
  3. Rash
  4. Malignant melanoma stage i (cancer has formed; the tumour is not more than 1 millimetre thick, with no ulceration)
  5. Malignant melanoma stage iii (cancer has spread to one or more lymph nodes)
  6. Acne (skin problems that cause pimples)
  7. Decreased interest
  8. Depressed mood
  9. Dysstasia (difficulty in standing)
  10. Pain in extremity

What are the common drug interactions of Valium and Motrin Ib, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Balance disorder
  2. Blood pressure increased
  3. Diplopia (double vision)
  4. Fibromyalgia (a long-term condition which causes pain all over the body)
  5. Inappropriate affect
  6. Nervousness
  7. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
  8. Snoring
  9. Somnolence (a state of near-sleep, a strong desire for sleep)
  10. Tooth disorder (tooth disease)

40-49:

  1. Flushing (the warm, red condition of human skin)
  2. Nausea (feeling of having an urge to vomit)
  3. Vomiting

50-59:

  1. Hepatic enzyme increased
  2. Pruritus (severe itching of the skin)
  3. Urticaria (rash of round, red welts on the skin that itch intensely)
  4. Androgens increased
  5. Metastases to central nervous system (cancer spreads to central nervous system)
  6. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
  7. Prostate cancer
  8. Rash
  9. Acne (skin problems that cause pimples)
  10. Decreased interest

60+:

  1. Death
  2. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
  3. Decreased appetite
  4. Dyspnoea (difficult or laboured respiration)
  5. Nausea (feeling of having an urge to vomit)
  6. Viral infection
  7. Malignant melanoma stage i (cancer has formed; the tumour is not more than 1 millimetre thick, with no ulceration)
  8. Malignant melanoma stage iii (cancer has spread to one or more lymph nodes)
  9. Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
  10. Capillary leak syndrome (capillary leaks plasma)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 24.24%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 24.24%
  3. Panic Disorder: 4 people, 12.12%
  4. High Blood Pressure: 4 people, 12.12%
  5. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 12.12%
  6. Depression: 4 people, 12.12%
  7. Muscle Spasms (muscle contraction): 3 people, 9.09%
  8. Immunodeficiency Common Variable: 3 people, 9.09%
  9. Sleep Disorder: 2 people, 6.06%
  10. Neuralgia (pain in one or more nerves): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Valium and Motrin ib:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Motrin ib:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Valium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Motrin ib and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on diazepam and ibuprofen (the active ingredients of Valium and Motrin ib, respectively), and Valium and Motrin ib (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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