Valium and Pentasa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valium (diazepam) and Pentasa (mesalamine). Common drug interactions include abdominal pain lower among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Valium and Pentasa. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Valium?

Valium has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 48,647 Valium users. Check the latest studies of Valium.

What is Pentasa?

Pentasa has active ingredients of mesalamine. It is often used in crohn's disease. eHealthMe is studying from 23,325 Pentasa users. Check the latest studies of Pentasa.

On Jul, 21, 2026

76 people who take Valium and Pentasa together, and have interactions are studied.

What are the common drug interactions of Valium and Pentasa, by gender? *:

female:

Abdominal pain lower
Depression
Diarrhoea
Dry mouth
Facial paralysis (loss of function of face muscle)
Flatulence (flatus expelled through the anus)
Hallucination (an experience involving the perception of something not present)
Migraine (headache)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

male:

Pyrexia (fever)
Hyperhidrosis (abnormally increased sweating)
Pain
Rectal haemorrhage (bleeding from anus)
Tonsillitis (inflammation of tonsil)
Accident
Anticonvulsant drug level increased
Chills (felling of cold)
Constipation
Dysuria (painful or difficult urination)

What are the common drug interactions of Valium and Pentasa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Hyperhidrosis (abnormally increased sweating)
Nervousness
Vomiting

20-29:

Vomiting
Abdominal pain
Depression
Rectal haemorrhage (bleeding from anus)
Dysuria (painful or difficult urination)
Inflammation
Intestinal obstruction
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Apnoea (suspension of external breathing)

30-39:

Drug ineffective
Diarrhoea
Pyrexia (fever)
Neuropathy peripheral (surface nerve damage)
Tonsillitis (inflammation of tonsil)
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal abscess (collection of pus in abdomen)
Abdominal distension
Abdominal pain

40-49:

Dyspnoea (difficult or laboured respiration)
Pain
Anaemia (lack of blood)
Arthropathy
Cardiac disorder
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Mitral valve incompetence (inefficient heart valve)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Pericardial effusion (fluid around the heart)

50-59:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Device occlusion
Diastolic dysfunction
Dizziness
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Inflammatory bowel disease
Injury
Intermittent claudication
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)

60+:

Fatigue (feeling of tiredness)
Confusional state
Suicidal ideation
Abdominal pain lower
Depression
Dry mouth
Facial paralysis (loss of function of face muscle)
Flatulence (flatus expelled through the anus)
Hallucination (an experience involving the perception of something not present)
Migraine (headache)

What are the existing conditions these people have? *

Pain: 14 people, 18.42%
Osteoporosis (bones weak and more likely to break): 10 people, 13.16%
High Blood Pressure: 9 people, 11.84%
Insomnia (sleeplessness): 7 people, 9.21%
Depression: 7 people, 9.21%
Sleep Disorder: 5 people, 6.58%
Nausea (feeling of having an urge to vomit): 5 people, 6.58%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 6.58%
Muscle Spasms (muscle contraction): 4 people, 5.26%
Migraine (headache): 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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