Valproate sodium and Augmentin '125' drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproate sodium (valproate sodium) and Augmentin '125' (amoxicillin; clavulanate potassium). Common drug interactions include anaemia among females and acute hepatic failure among males.

The phase IV clinical study analyzes what interactions people have when they take Valproate sodium and Augmentin '125'. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

What is Augmentin '125'?

Augmentin '125' has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 10,452 Augmentin '125' users. Check the latest studies of Augmentin '125'.

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On Aug, 19, 2026

15 people who take Valproate sodium and Augmentin '125' together, and have interactions are studied.

Valproate sodium and Augmentin '125' drug interactions.

What are the common drug interactions of Valproate Sodium and Augmentin '125', by gender? *:

female:

Anaemia (lack of blood)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Leukocytoclastic vasculitis (inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Overdose
Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Abdominal pain
Acidosis (build-up of carbon dioxide in the blood)

male:

Acute hepatic failure
Arthralgia (joint pain)
Hypoxia (low oxygen in tissues)
Lymphadenopathy (disease or enlargement of lymph nodes)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oedema peripheral (superficial swelling)
Pain
Pyrexia (fever)

What are the common drug interactions of Valproate Sodium and Augmentin '125', by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abdominal pain
Pancreatitis acute (sudden inflammation of pancreas)
Acute hepatic failure

10-19:

n/a

20-29:

Acidosis (build-up of carbon dioxide in the blood)
Blood pressure decreased
Depressed level of consciousness
Overdose
Oxygen saturation decreased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Lymphadenopathy (disease or enlargement of lymph nodes)
Rash

30-39:

Blood alkaline phosphatase increased
Blood bilirubin increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Gamma-glutamyltransferase increased

40-49:

n/a

50-59:

Blood creatine phosphokinase increased
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)
Hypocapnia (level of carbon dioxide in the blood is lower than normal)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Inferior vena caval occlusion
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

60+:

Anaemia (lack of blood)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Leukocytoclastic vasculitis (inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot)
Neutropenia (an abnormally low number of neutrophils)
Tardive dyskinesia (a disorder that involves involuntary movements)
White blood cell count decreased

What are the existing conditions these people have? *

Upper Respiratory Tract Infection: 2 people, 13.33%
Neutropenic Infection (infection with less neutrophil numbers in blood): 2 people, 13.33%
Multiple Myeloma (cancer of the plasma cells): 2 people, 13.33%
Sleep Disorder: 1 person, 6.67%
High Blood Cholesterol: 1 person, 6.67%
Bipolar Disorder (mood disorder): 1 person, 6.67%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 6.67%
Breakthrough Pain: 1 person, 6.67%
Chest Pain: 1 person, 6.67%
Depression: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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