Valproate sodium and Humalog drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproate sodium (valproate sodium) and Humalog (insulin lispro recombinant). Common drug interactions include sopor among females and bradykinesia among males.

The phase IV clinical study analyzes what interactions people have when they take Valproate sodium and Humalog. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

What is Humalog?

Humalog has active ingredients of insulin lispro recombinant. It is often used in diabetes. eHealthMe is studying from 137,127 Humalog users. Check the latest studies of Humalog.



On Jul, 14, 2026

35 people who take Valproate sodium and Humalog together, and have interactions are studied.

Valproate sodium and Humalog drug interactions.

What are the common drug interactions of Valproate Sodium and Humalog, by gender? *:

female:

  1. Sopor (sleep)
  2. Cardiac death
  3. Diabetes mellitus inadequate control
  4. Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)
  5. Drug abuse
  6. Coeliac disease (simple food intolerance)
  7. Hypoglycaemia (deficiency of glucose in the bloodstream)
  8. Constipation
  9. Suicide attempt
  10. Abdominal pain upper

male:

  1. Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
  2. Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
  3. Oedema peripheral (superficial swelling)
  4. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  5. Suicide attempt
  6. Adverse event
  7. Aggression
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  9. Exsanguination (process of blood loss, to a degree sufficient to cause death)
  10. Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)

What are the common drug interactions of Valproate Sodium and Humalog, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Coeliac disease (simple food intolerance)
  2. Hypoglycaemia (deficiency of glucose in the bloodstream)
  3. Suicide attempt

30-39:

  1. Cardiac death
  2. Diabetes mellitus inadequate control
  3. Generalised anxiety disorder (excessive, uncontrollable, unexplained and often irrational worry)

40-49:

  1. Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
  2. Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)
  3. Hypoglycaemia (deficiency of glucose in the bloodstream)
  4. Hypotension (abnormally low blood pressure)
  5. Somnolence (a state of near-sleep, a strong desire for sleep)
  6. Suicide attempt
  7. Blood insulin abnormal
  8. Dehydration (dryness resulting from the removal of water)
  9. Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
  10. Loss of consciousness

50-59:

  1. Arthralgia (joint pain)
  2. Cutaneous vasculitis (an inflammatory process affecting the vessel wall that leads to its damage)
  3. Oedema peripheral (superficial swelling)
  4. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  5. Constipation
  6. Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
  7. Malaise (a feeling of general discomfort or uneasiness)

60+:

  1. Sopor (sleep)
  2. Drug abuse
  3. Constipation
  4. Exsanguination (process of blood loss, to a degree sufficient to cause death)
  5. Flatulence (flatus expelled through the anus)
  6. Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
  7. Intentional self-injury
  8. Liver disorder (liver diseases)
  9. Loss of consciousness
  10. Melaena (the passage of black, tarry stools)

What are the existing conditions these people have? *

  1. Suicide Attempt: 3 people, 8.57%
  2. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 8.57%
  3. Pyelonephritis Acute (sudden inflammation of kidney caused by bacteria): 2 people, 5.71%
  4. High Blood Pressure: 2 people, 5.71%
  5. High Blood Cholesterol: 2 people, 5.71%
  6. Depression: 2 people, 5.71%
  7. Constipation: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Valproate sodium and Humalog:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproate sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Humalog:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Valproate sodium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Humalog and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on valproate sodium and insulin lispro recombinant (the active ingredients of Valproate sodium and Humalog, respectively), and Valproate sodium and Humalog (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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