Valproate sodium and Latuda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproate sodium (valproate sodium) and Latuda (lurasidone hydrochloride). Common drug interactions include obsessive-compulsive disorder among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Valproate sodium and Latuda. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Valproate sodium?

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. eHealthMe is studying from 24,044 Valproate sodium users. Check the latest studies of Valproate sodium.

What is Latuda?

Latuda has active ingredients of lurasidone hydrochloride. It is often used in bipolar disorder. eHealthMe is studying from 21,543 Latuda users. Check the latest studies of Latuda.

On Jul, 27, 2026

82 people who take Valproate sodium and Latuda together, and have interactions are studied.

Valproate sodium and Latuda drug interactions.

What are the common drug interactions of Valproate Sodium and Latuda, by gender? *:

female:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pancreatitis (inflammation of pancreas)
Psychomotor hyperactivity (feelings of extreme restlessness)
Pyrexia (fever)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Speech disorder
Abdominal pain
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Completed suicide (act of taking one's own life)

male:

Drug ineffective
Weight increased
Dyslipidaemia (abnormal amount of lipids)
Dystonia (abnormal muscle tone)
Euphoric mood (excessively happy but may become angry or irritable)
Hypertension (high blood pressure)
Leukaemia (blood or bone marrow cancer)
Leukopenia (less number of white blood cells in blood)
Metabolic disorder (an abnormal function and pattern of body fat. insulin resistance refers to the diminished ability of cells to respond to the action of insulin in promoting the transport of the sugar glucose, from blood into muscles and other tissues)
Obesity (having too much body fat)

What are the common drug interactions of Valproate Sodium and Latuda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug ineffective
Anxiety
Blunted affect (lack of emotional reactivity)
Depressed mood
Disturbance in attention
Muscle rigidity (muscle stiffness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tremor (trembling or shaking movements in one or more parts of your body)
Bradykinesia (decreased bodily movement. it is associated with basal ganglia diseases)
Erectile dysfunction

20-29:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Hyperphagia (an abnormal appetite for food)
Impulsive behaviour
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

30-39:

Delusion (a false belief or opinion)
Dizziness
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Headache (pain in head)
Pyrexia (fever)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Abdominal pain
Drug abuse
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)

40-49:

Altered state of consciousness (altered state of mind)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Persecutory delusion
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anosognosia (ignorance of the presence of disease)
Blood glucose increased
Disinhibition (loss of inhibition)
Disturbance in social behaviour
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)

50-59:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Dry eye (lack of adequate tears)
Eyelid ptosis (falling of the upper or lower eyelid)
Facial spasm (involuntary muscle contractions face)
Gait disturbance
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Urinary retention (the inability to completely or partially empty the bladder)
Antipsychotic drug level increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

60+:

Mania (a state of abnormally elevated or irritable mood)
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Drug eruption (adverse drug reaction of the skin)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Renal impairment (severely reduced kidney function)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Pyrexia (fever)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Suicide attempt

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 26 people, 31.71%
Insomnia (sleeplessness): 12 people, 14.63%
Depression: 10 people, 12.20%
Affective Disorder (mental disorder): 9 people, 10.98%
Psychotic Disorder: 8 people, 9.76%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 6 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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