Valproic acid and Caffeine citrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproic acid (valproic acid) and Caffeine citrate (caffeine citrate). Common drug interactions include anaemia among females and arrhythmia among males.

The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Caffeine citrate. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Caffeine citrate?

Caffeine citrate has active ingredients of caffeine citrate. It is often used in fatigue. eHealthMe is studying from 2,424 Caffeine citrate users. Check the latest studies of Caffeine citrate.

On Jul, 16, 2026

11 people who take Valproic acid and Caffeine citrate together, and have interactions are studied.

Valproic acid and Caffeine citrate drug interactions.

What are the common drug interactions of Valproic Acid and Caffeine Citrate, by gender? *:

female:

Anaemia (lack of blood)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug abuse
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Irritability

male:

Arrhythmia (irregular heartbeat)
Electrocardiogram t wave inversion
Palpitations (feelings or sensations that your heart is pounding or racing)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Anaemia (lack of blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Panic attack
Suicidal ideation
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)

What are the common drug interactions of Valproic Acid and Caffeine Citrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Anaemia (lack of blood)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)

10-19:

Arrhythmia (irregular heartbeat)
Electrocardiogram t wave inversion
Palpitations (feelings or sensations that your heart is pounding or racing)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

20-29:

Accidental poisoning
Cardiomegaly (increased size of heart than normal)
Substance abuse

30-39:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Irritability
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Overdose
Pancreatitis acute (sudden inflammation of pancreas)
Sleep disorder
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Panic attack
Suicidal ideation
Confusional state
Hallucination (an experience involving the perception of something not present)
Sedation

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Tension Headache: 2 people, 18.18%
Sleep Disorder: 2 people, 18.18%
Lymphoma (cancer that begins in immune system cells): 2 people, 18.18%
Feeling Abnormal: 2 people, 18.18%
Stress And Anxiety: 1 person, 9.09%
Psychotic Disorder: 1 person, 9.09%
Pain: 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%
Affective Disorder (mental disorder): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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