Valproic acid and Dilaudid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproic acid (valproic acid) and Dilaudid (hydromorphone hydrochloride). Common drug interactions include bursitis among females and cardiac arrest among males.

The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Dilaudid. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Dilaudid?

Dilaudid has active ingredients of hydromorphone hydrochloride. It is often used in pain. eHealthMe is studying from 96,466 Dilaudid users. Check the latest studies of Dilaudid.

On Aug, 01, 2026

35 people who take Valproic acid and Dilaudid together, and have interactions are studied.

Valproic acid and Dilaudid drug interactions.

What are the common drug interactions of Valproic Acid and Dilaudid, by gender? *:

female:

Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Butterfly rash
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)
Chest discomfort
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Claustrophobia (fear of having no escape and being closed in small spaces)
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Completed suicide (act of taking one's own life)
Confusional state

male:

Cardiac arrest
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Muscle spasms (muscle contraction)
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other)
Injury
Overdose
Road traffic accident
Urticaria (rash of round, red welts on the skin that itch intensely)
Dysphagia (a condition in which swallowing is difficult or painful)
Fall

What are the common drug interactions of Valproic Acid and Dilaudid, by age (0-1 to 60+)? *:

0-1:

Abdominal pain
Abscess (pus)
Anaemia (lack of blood)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Colitis ulcerative (inflammation of colon with ulcer)
Constipation
Dehydration (dryness resulting from the removal of water)
Depression
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)

2-9:

n/a

10-19:

Leukaemia recurrent (repeat cancer of bone marrow or blood cells)

20-29:

Bradycardia (abnormally slow heart action)
Chest discomfort
Chills (felling of cold)
Device failure
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Feeling hot
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Influenza

30-39:

Constipation
Weight increased
Headache (pain in head)
Abdominal pain
Abscess (pus)
Anaemia (lack of blood)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Colitis ulcerative (inflammation of colon with ulcer)
Dehydration (dryness resulting from the removal of water)
Depression

40-49:

Joint effusion (presence of extra fluid in joint covering)
Joint swelling
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Leukocytosis (increased white blood cells)
Ligament sprain (ligament stretched)
Lipoma (a growth of fatty tissue that slowly develops just under your skin)
Lumbar spine flattening (flatten the curve of the lower spine)
Lung consolidation (a condition whereby the lung tissues solidify because of the accumulation of solid and liquid material in the air spaces)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Lung neoplasm malignant (cancer tumour of lung)

50-59:

Impulsive behaviour
Suicidal ideation
Suicide attempt
Drug hypersensitivity

60+:

Blood creatinine increased
Cardiac arrest
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Death
Acute myocardial infarction (acute heart attack)
Pneumonia
Staphylococcal infection (an infection with staphylococcus bacteria)
Thrombotic microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury)

What are the existing conditions these people have? *

Depression: 6 people, 17.14%
Asthma: 5 people, 14.29%
High Blood Pressure: 4 people, 11.43%
Stress And Anxiety: 4 people, 11.43%
Sleep Disorder: 4 people, 11.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 11.43%
Constipation: 3 people, 8.57%
Hypersensitivity: 3 people, 8.57%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 8.57%
Dry Skin: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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