Valproic acid and Hydroxychloroquine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valproic acid (valproic acid) and Hydroxychloroquine sulfate (hydroxychloroquine sulfate). Common drug interactions include fatigue among females and respiratory arrest (excl neonatal) among males.

The phase IV clinical study analyzes what interactions people have when they take Valproic acid and Hydroxychloroquine sulfate. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Hydroxychloroquine sulfate?

Hydroxychloroquine sulfate has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis. eHealthMe is studying from 52,084 Hydroxychloroquine sulfate users. Check the latest studies of Hydroxychloroquine sulfate.

On Aug, 11, 2026

20 people who take Valproic acid and Hydroxychloroquine sulfate together, and have interactions are studied.

Valproic acid and Hydroxychloroquine sulfate drug interactions.

What are the common drug interactions of Valproic Acid and Hydroxychloroquine Sulfate, by gender? *:

female:

Fatigue (feeling of tiredness)
Vision blurred
Tremor (trembling or shaking movements in one or more parts of your body)
Electrocardiogram qt prolonged
Biliary cirrhosis primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. the build-up of bile damages the liver)
Blood albumin decreased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Drug ineffective
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)

male:

Respiratory arrest (excl neonatal) (cessation of normal respiration due to failure of the lungs to function effectively (excluding neonatal))
Aggression
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug screen positive
Hypertensive heart disease
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Hypokinesia (decreased bodily movement)
Mental disability
Neuromyopathy (disease of both muscles and nerves)
Pulmonary oedema (fluid accumulation in the lungs)

What are the common drug interactions of Valproic Acid and Hydroxychloroquine Sulfate, by age (0-1 to 60+)? *:

0-1:

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Hypokinesia (decreased bodily movement)
Mental disability
Neuromyopathy (disease of both muscles and nerves)
Speech disorder

2-9:

Cardiovascular disorder (heart diseases)
Chills (felling of cold)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dizziness
Drug ineffective
Fall
Feeling cold
Hypersensitivity
Malaise (a feeling of general discomfort or uneasiness)
Peripheral vascular disorder

10-19:

Completed suicide (act of taking one's own life)
Drug toxicity

20-29:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

30-39:

Atrioventricular block first degree (heart block first degree)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Hypertrophic cardiomyopathy (a condition in which the heart muscle becomes abnormally thick)
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug screen positive
Hypertensive heart disease
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory arrest (excl neonatal) (cessation of normal respiration due to failure of the lungs to function effectively (excluding neonatal))
Arrhythmia (irregular heartbeat)
Cardiomegaly (increased size of heart than normal)
Cardiovascular disorder (heart diseases)

50-59:

n/a

60+:

Electrocardiogram qt prolonged
Aggression
Agitation (state of anxiety or nervous excitement)
Delirium (wild excitement)
Psychotic disorder
Suicide attempt

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 4 people, 20.00%
Ulcerative Keratitis (ulcerative inflammation of the cornea): 2 people, 10.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 10.00%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 2 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.00%
Hypersensitivity: 2 people, 10.00%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 1 person, 5.00%
Lung Disorder (lung disease): 1 person, 5.00%
Infantile Spasms: 1 person, 5.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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