Vancomycin and Sulfamethoxazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vancomycin (vancomycin) and Sulfamethoxazole (sulfamethoxazole). Common drug interactions include hyperparathyroidism secondary among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Vancomycin and Sulfamethoxazole. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Vancomycin?

Vancomycin has active ingredients of vancomycin. eHealthMe is studying from 17,165 Vancomycin users. Check the latest studies of Vancomycin.

What is Sulfamethoxazole?

Sulfamethoxazole has active ingredients of sulfamethoxazole. It is often used in urinary tract infection. eHealthMe is studying from 13,360 Sulfamethoxazole users. Check the latest studies of Sulfamethoxazole.

On Jul, 27, 2026

90 people who take Vancomycin and Sulfamethoxazole together, and have interactions are studied.

Vancomycin and Sulfamethoxazole drug interactions.

What are the common drug interactions of Vancomycin and Sulfamethoxazole, by gender? *:

female:

Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nerve injury
Pyrexia (fever)
Scar
Staphylococcal infection (an infection with staphylococcus bacteria)
Wound
Abscess (pus)
Arthralgia (joint pain)
Cardiac failure congestive
Constipation

male:

Anxiety
Emotional distress
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Renal impairment (severely reduced kidney function)
Anal abscess
Drug ineffective
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Perirectal abscess
Scrotal abscess (pus in scrotum)
Abscess limb (limb infection)

What are the common drug interactions of Vancomycin and Sulfamethoxazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Febrile neutropenia (fever with reduced white blood cells)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Corynebacterium infection (infection by corynebacterium (diphtheria))
Klebsiella infection
Pneumonia bacterial (pneumonia associated with bacterial infection)
Staphylococcal infection (an infection with staphylococcus bacteria)
Thrombocytopenia (decrease of platelets in blood)

10-19:

Death
Inflammation
Respiratory distress (difficulty in breathing)
Arthralgia (joint pain)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Confusional state
Disease progression
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug level below therapeutic
Drug level increased

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Anaemia (lack of blood)
Asthenia (weakness)
Chronic kidney disease
Fatigue (feeling of tiredness)
Osteopenia (a condition where bone mineral density is lower than normal)
Renal impairment (severely reduced kidney function)

30-39:

Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Pain
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)
Renal failure (kidney dysfunction)
Anxiety
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Gastritis (inflammation of stomach)

40-49:

Renal failure (kidney dysfunction)
Cellulitis (infection under the skin)
Chronic kidney disease
Sepsis (a severe blood infection that can lead to organ failure and death)
Groin abscess (pus in groin)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perirectal abscess
Abscess limb (limb infection)
Acute respiratory failure
Anal abscess

50-59:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pericardial effusion (fluid around the heart)
Post-traumatic stress disorder
Psoriasis (immune-mediated disease that affects the skin)
Renal tubular necrosis (death of kidney tubules)
Scrotal abscess (pus in scrotum)
Scrotal cyst (cyst of scrotum)
Scrotal gangrene (death of scrotum cells)
Scrotal pain
Scrotal swelling

60+:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Neutropenia (an abnormally low number of neutrophils)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Renal failure (kidney dysfunction)
Blood immunoglobulin a increased
Linear iga disease (a rare, idiopathic or drug-induced autoimmune blistering disease of skin)
Abdominal wall infection
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Anaemia (lack of blood)

What are the existing conditions these people have? *

Pain: 30 people, 33.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 25 people, 27.78%
High Blood Pressure: 19 people, 21.11%
Hiv Infection: 18 people, 20.00%
Infection: 18 people, 20.00%
Weight Decreased: 15 people, 16.67%
Type 2 Diabetes: 14 people, 15.56%
High Blood Cholesterol: 13 people, 14.44%
Hypotension (abnormally low blood pressure): 12 people, 13.33%
Diabetes: 9 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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