Venofer and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Venofer (iron sucrose) and Profen (ibuprofen). Common drug interactions include intestinal obstruction among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Venofer and Profen. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Venofer?

Venofer has active ingredients of iron sucrose. It is often used in anemia. eHealthMe is studying from 8,895 Venofer users. Check the latest studies of Venofer.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

98 people who take Venofer and Profen together, and have interactions are studied.

What are the common drug interactions of Venofer and Profen, by gender? *:

female:

Intestinal obstruction
Intestinal perforation (complete penetration of the wall of the intestine)
Large intestine perforation (hole in large intestine)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Anaemia (lack of blood)
Pain in extremity
Pneumonia
Pruritus (severe itching of the skin)
Abdominal pain upper
Anxiety

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Hypertension (high blood pressure)
Staphylococcal infection (an infection with staphylococcus bacteria)
Upper limb fracture
Nephrogenic anaemia (anaemia due to kidney disease)
Diarrhoea
Emotional distress
Fatigue (feeling of tiredness)
Heart rate increased

What are the common drug interactions of Venofer and Profen, by age (0-1 to 60+)? *:

0-1:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertension (high blood pressure)
Infection
Respiratory distress (difficulty in breathing)
Therapeutic response decreased (less preventive response)
Transplant rejection (a transplant material is not worked)
Leukopenia (less number of white blood cells in blood)

2-9:

Fall
Pseudomonal bacteraemia (p. aeruginosa cause of bacterial infections of the blood)
Tracheobronchitis (an inflammation or infection, which affects the trachea and bronchi of respiratory tract)
Central line infection (infection by central line in icu)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Staphylococcal infection (an infection with staphylococcus bacteria)
Upper limb fracture
Heart rate increased
Oxygen saturation decreased
Retching (strong involuntary effort to vomit)

10-19:

Septic shock (shock due to blood infection)

20-29:

n/a

30-39:

Multiple fractures
Road traffic accident
Abdominal pain
Abdominal pain upper
Duodenitis (inflammation of the duodenum)
Foetal death (death of foetus)
Gastritis (inflammation of stomach)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Maternal exposure during pregnancy (use of substance during pregnancy)
Melaena (the passage of black, tarry stools)

40-49:

Abdominal abscess (collection of pus in abdomen)
Abscess intestinal (collections of pus-intestinal)
Colonic obstruction (obstruction in colon)
Intestinal obstruction
Intestinal perforation (complete penetration of the wall of the intestine)
Large intestine perforation (hole in large intestine)
Urticaria (rash of round, red welts on the skin that itch intensely)
Chronic kidney disease
Colon cancer
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

50-59:

Mobility decreased (ability to move is reduced)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Depression
Fear
Migraine (headache)
Pain in extremity
Quality of life decreased
Anaemia (lack of blood)

60+:

Anaemia (lack of blood)
Chronic kidney disease
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Coagulopathy (blood's ability to clot is impaired)
Death
Dyspnoea (difficult or laboured respiration)
Erosive oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time)
Fall
Myalgia (muscle pain)

What are the existing conditions these people have? *

High Blood Pressure: 18 people, 18.37%
Anaemia (lack of blood): 17 people, 17.35%
Stress And Anxiety: 12 people, 12.24%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 11.22%
Iron Deficiency: 9 people, 9.18%
Infection: 9 people, 9.18%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 9 people, 9.18%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 9 people, 9.18%
Headache (pain in head): 8 people, 8.16%
Diarrhea: 8 people, 8.16%

* Approximation only. Some reports may have incomplete information.

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