Vesicare and Nyquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vesicare (solifenacin succinate) and Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine). Common drug interactions include immunodeficiency among females and glossitis among males.

The phase IV clinical study analyzes what interactions people have when they take Vesicare and Nyquil. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Vesicare?

Vesicare has active ingredients of solifenacin succinate. It is often used in urge incontinence. eHealthMe is studying from 30,655 Vesicare users. Check the latest studies of Vesicare.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

22 people who take Vesicare and Nyquil together, and have interactions are studied.

What are the common drug interactions of Vesicare and Nyquil, by gender? *:

female:

Immunodeficiency
Malaise (a feeling of general discomfort or uneasiness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Overdose
Pain in extremity
Paralysis
Post-traumatic stress disorder
Psychotic disorder
Respiration (transport of oxygen from the outside air to the cells within tissues)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Glossitis (infection of tongue with soreness)
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Vesicare and Nyquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Pneumonia
Infection
Pain
Pain in extremity
Pyrexia (fever)
Respiration (transport of oxygen from the outside air to the cells within tissues)
Swollen tongue (swelling of tongue)
Cellulitis (infection under the skin)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Furuncle (infection of the hair follicle)

30-39:

Psychotic disorder
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Suicidal ideation
Suicide attempt
Wound
Fall
Hypnagogic hallucination
Malaise (a feeling of general discomfort or uneasiness)
Surgery
Anxiety

40-49:

n/a

50-59:

n/a

60+:

Glossitis (infection of tongue with soreness)
Nasopharyngitis (inflammation of the nasopharynx)

What are the existing conditions these people have? *

Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 10 people, 45.45%
Skin Blushing/flushing (a sudden reddening of the face, neck): 4 people, 18.18%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 13.64%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 13.64%
Multiple Myeloma (cancer of the plasma cells): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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