Vfend and Cytoxan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vfend (voriconazole) and Cytoxan (cyclophosphamide). Common drug interactions include pyrexia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Vfend and Cytoxan. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Vfend?

Vfend has active ingredients of voriconazole. It is often used in aspergillosis. eHealthMe is studying from 12,128 Vfend users. Check the latest studies of Vfend.

What is Cytoxan?

Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.

On Jul, 19, 2026

23 people who take Vfend and Cytoxan together, and have interactions are studied.

What are the common drug interactions of Vfend and Cytoxan, by gender? *:

female:

Pyrexia (fever)
Dysuria (painful or difficult urination)
Haematuria (presence of blood in urine)
Micturition urgency (urgency to pass the urine)
Cystitis viral (inflammation of the wall of the bladder by virus)
Discomfort
Neuropathy peripheral (surface nerve damage)
Polyomavirus test positive
Rhinorrhoea (watery mucus discharge from the nose)
Sinus congestion (blockage of sinus)

male:

Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Blood glucose increased
Blood lactate dehydrogenase increased
Blood phosphorus decreased
Blood potassium decreased
Blood triglycerides increased
Carbon dioxide decreased
Haematocrit decreased
Liver injury

What are the common drug interactions of Vfend and Cytoxan, by age (0-1 to 60+)? *:

0-1:

Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Ammonia decreased
Anion gap increased
Aspartate aminotransferase increased
Blast cell count increased
Blood albumin decreased
Blood calcium decreased
Blood chloride increased

2-9:

Cystitis (inflammation of the wall of the bladder)
Glucose urine present
Pneumonia fungal
Skin disorder (skin disease)

10-19:

Chest discomfort
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
Coagulopathy (blood's ability to clot is impaired)
Confusional state
Cough
Delirium (wild excitement)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Electrocardiogram qt prolonged
Encephalopathy (functioning of the brain is affected by some agent or condition)

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)

30-39:

n/a

40-49:

n/a

50-59:

Pyrexia (fever)
Cystitis (inflammation of the wall of the bladder)
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Haematuria (presence of blood in urine)
Haemorrhage urinary tract (bleeding from uterine)
Influenza
Micturition urgency (urgency to pass the urine)
Oedema peripheral (superficial swelling)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

60+:

Pyrexia (fever)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Haematemesis (vomiting of blood)
Haematochezia (passage of stools containing blood)
Haematuria (presence of blood in urine)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Melaena (the passage of black, tarry stools)

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 21.74%
Bone Marrow Conditioning Regimen: 4 people, 17.39%
Nausea (feeling of having an urge to vomit): 4 people, 17.39%
Fungal Infection: 4 people, 17.39%
White Blood Cell Disorder: 2 people, 8.70%
High Blood Cholesterol: 2 people, 8.70%
Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 2 people, 8.70%
Constipation: 2 people, 8.70%
Dehydration (dryness resulting from the removal of water): 2 people, 8.70%
Depression: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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