Vicodin and Percodan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vicodin (acetaminophen; hydrocodone bitartrate) and Percodan (aspirin; oxycodone hydrochloride; oxycodone terephthalate). Common drug interactions include depression among females and impaired gastric emptying among males.

The phase IV clinical study analyzes what interactions people have when they take Vicodin and Percodan. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Percodan?

Percodan has active ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate. It is often used in pain. eHealthMe is studying from 12,885 Percodan users. Check the latest studies of Percodan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

89 people who take Vicodin and Percodan together, and have interactions are studied.

What are the common drug interactions of Vicodin and Percodan, by gender? *:

female:

Depression
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Nervousness
Abdominal pain
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Emotional distress
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Influenza like illness

male:

Impaired gastric emptying
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Activated partial thromboplastin time prolonged
Cholecystitis (infection of gallbladder)
Cholecystitis chronic (long lasting infection of gallbladder)
Oesophagitis (inflammation of oesophagus)
Blood albumin decreased
Blood bilirubin increased
Hepatic failure (liver failure)

What are the common drug interactions of Vicodin and Percodan, by age (0-1 to 60+)? *:

0-1:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)

2-9:

n/a

10-19:

Arthralgia (joint pain)
Rash
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Drug hypersensitivity
Rash erythematous (redness of the skin)
Blood albumin decreased
Blood calcium decreased
Blood urea decreased
Fatigue (feeling of tiredness)
Gallbladder disorder

20-29:

Vomiting

30-39:

Depression
Anxiety
Dependence
Disturbance in attention
Drug dependence
Insomnia (sleeplessness)
Loss of consciousness
Memory impairment
Neck pain
Nervousness

40-49:

Haematuria present (presence of blood in urine due to trauma)
Hepatic failure (liver failure)
Urobilinuria present
Abdominal pain upper
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blood bilirubin increased
Blood urea increased
Bone pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cold sweat

50-59:

Hyperhidrosis (abnormally increased sweating)
Influenza like illness
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nervousness
Vomiting
Weight decreased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Atherosclerosis (disorder of the arteries)
Feeling hot

60+:

Drug hypersensitivity
Constipation
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Bloody discharge
Candidiasis (candidiasis or thrush is a fungal infection)
Cardiac valve vegetation (heart valve abnormal growth)
Chest discomfort
Cholecystitis acute (rapid infection of gallbladder)

What are the existing conditions these people have? *

Migraine (headache): 6 people, 6.74%

* Approximation only. Some reports may have incomplete information.

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