Vicodin and Silodosin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vicodin (acetaminophen; hydrocodone bitartrate) and Silodosin (silodosin). Common drug interactions include left ventricular failure among males.

The phase IV clinical study analyzes what interactions people have when they take Vicodin and Silodosin. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Silodosin?

Silodosin has active ingredients of silodosin. eHealthMe is studying from 3,839 Silodosin users. Check the latest studies of Silodosin.



On Jul, 07, 2026

13 people who take Vicodin and Silodosin together, and have interactions are studied.

Vicodin and Silodosin drug interactions.

What are the common drug interactions of Vicodin and Silodosin, by gender? *:

female:

n/a

male:

  1. Left ventricular failure (left ventricle fails to contract forcefully)
  2. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  3. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  4. Dizziness
  5. Electrolyte imbalance
  6. Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
  7. Full blood count decreased
  8. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  9. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  10. Hearing impaired

What are the common drug interactions of Vicodin and Silodosin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Left ventricular failure (left ventricle fails to contract forcefully)
  2. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  3. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  4. Dizziness
  5. Electrolyte imbalance
  6. Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
  7. Full blood count decreased
  8. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  9. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  10. Hearing impaired

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 7 people, 53.85%
  2. High Blood Pressure: 6 people, 46.15%
  3. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 38.46%
  4. Herpes Zoster: 4 people, 30.77%
  5. Burkitt Lymphoma (cancer of the lymphatic system): 4 people, 30.77%
  6. Constipation: 4 people, 30.77%
  7. Cough: 4 people, 30.77%
  8. Enlarged Prostate: 4 people, 30.77%
  9. Glaucoma (increased fluid pressure in the eye with vision loss): 4 people, 30.77%
  10. Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 30.77%

* Approximation only. Some reports may have incomplete information.

Do you take Vicodin and Silodosin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Vicodin and Silodosin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vicodin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Silodosin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Vicodin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Silodosin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate and silodosin (the active ingredients of Vicodin and Silodosin, respectively), and Vicodin and Silodosin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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