Vimovo and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vimovo (esomeprazole magnesium; naproxen) and Melatonin (melatonin). Common drug interactions include pyrexia among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Vimovo and Melatonin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Vimovo?

Vimovo has active ingredients of esomeprazole magnesium; naproxen. It is often used in osteoarthritis. eHealthMe is studying from 9,608 Vimovo users. Check the latest studies of Vimovo.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,213 Melatonin users. Check the latest studies of Melatonin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

21 people who take Vimovo and Melatonin together, and have interactions are studied.

What are the common drug interactions of Vimovo and Melatonin, by gender? *:

female:

Pyrexia (fever)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Upper respiratory tract infection
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aphasia (damage to the parts of the brain that control language)
Arrhythmia (irregular heartbeat)
Behcet's syndrome (involves inflammation of the blood vessels)
Blood cannabinoids increased (increased cannabinoids in blood and urine after passive inhalation of cannabis smoke)
Bone pain

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Failure to thrive (inadequate weight gain and physical growth in children)
Nephrogenic anaemia (anaemia due to kidney disease)
Death

What are the common drug interactions of Vimovo and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal discomfort
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Behcet's syndrome (involves inflammation of the blood vessels)
Blood cannabinoids increased (increased cannabinoids in blood and urine after passive inhalation of cannabis smoke)
Fibromyalgia (a long-term condition which causes pain all over the body)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Total lung capacity decreased
Visual field defect

40-49:

Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)

50-59:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Aphasia (damage to the parts of the brain that control language)
Arrhythmia (irregular heartbeat)
Carotid artery stenosis (narrowing of carotid artery)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Confusional state
Cough
Drug hypersensitivity
Dyspepsia (indigestion)
Fall

60+:

Chronic kidney disease
Failure to thrive (inadequate weight gain and physical growth in children)
Mycobacterium avium complex infection
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Pyrexia (fever)
Upper respiratory tract infection
Abdominal discomfort

What are the existing conditions these people have? *

Pain: 7 people, 33.33%
Nausea (feeling of having an urge to vomit): 5 people, 23.81%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 19.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 14.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 14.29%
High Blood Cholesterol: 3 people, 14.29%
Gastric Ulcer (stomach ulcer): 3 people, 14.29%
Diabetes: 3 people, 14.29%
Erythema Nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below): 2 people, 9.52%
Blood Pressure Abnormal: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Vimovo and Melatonin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously